{"id":"W4410131331","doi":"10.1021/acschembio.5c00158","title":"Selective Small-Molecule Activator of Patient-Derived GPX4 Variant","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Columbia University","keywords":"Activator (genetics); Chemistry; Small molecule; Computational biology; Biology; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279018,0.0004692334,0.0004898679,0.0002620299,0.0001116814,0.000246977,0.0003038238,0.0004032604,0.002023588],"category_scores_gemma":[0.0001556325,0.0001709352,0.0002913842,0.0002847204,0.0001491306,0.0001028032,0.0001960959,0.0005978736,0.0004912002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003494727,"about_ca_system_score_gemma":0.0002467099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000566034,"about_ca_topic_score_gemma":0.001662547,"domain_scores_codex":[0.9998878,0.00001809968,0.000007347948,0.00003052308,0.00002592901,0.00003018934],"domain_scores_gemma":[0.9999518,0.00001259268,0.000009619096,0.000006330234,0.00000735099,0.00001222375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003155157,0.0002335597,0.0005036257,0.0001187041,0.00004312479,0.0003246232,0.00003762157,0.00088643,0.9863036,0.000244543,0.00043224,0.01055634],"study_design_scores_gemma":[0.0004451548,0.004785074,0.002607118,0.00001806664,0.0001085816,0.001580439,0.00004455474,0.002028143,0.9778635,0.000104693,0.01039012,0.00002458098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885674,0.003070518,0.002675012,0.0001830809,0.00005736401,0.0002254944,0.001123164,0.0001729139,0.00392504],"genre_scores_gemma":[0.9884958,0.001939221,0.002899517,0.0001543011,0.00001546947,0.0001114344,0.00189844,0.00002819158,0.004457541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023588,"threshold_uncertainty_score":0.006769538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005873499841731589,"score_gpt":0.2482421614161834,"score_spread":0.2423686615744518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}