{"id":"W4410131331","doi":"10.1021/acschembio.5c00158","title":"Selective Small-Molecule Activator of Patient-Derived GPX4 Variant","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Columbia University","keywords":"Activator (genetics); Chemistry; Small molecule; Computational biology; Biology; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008554471,0.0001608619,0.0002712155,0.00005076537,0.00004107752,0.000003586726,0.0001874202,0.0004775758,0.00000885789],"category_scores_gemma":[0.0002324615,0.00013303,0.00008764453,0.0001729432,0.0001716522,0.000001490796,0.00016147,0.0001509425,0.000006602128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002578971,"about_ca_system_score_gemma":0.0001924633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003861741,"about_ca_topic_score_gemma":0.00000272426,"domain_scores_codex":[0.9988505,0.0001076596,0.0003130313,0.0003941475,0.00004045269,0.0002942239],"domain_scores_gemma":[0.9993511,0.00004454371,0.0001321418,0.0002594166,0.0001408563,0.00007196707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704431,0.0001081377,0.001164554,0.00003663187,0.0001660955,0.000001536845,0.00003618174,7.405953e-7,0.9950687,0.001451238,0.0006690929,0.001126618],"study_design_scores_gemma":[0.0005424112,0.0002985134,0.0002787505,0.00003042825,0.00001996393,0.000007375204,0.00004673293,0.000002074773,0.9940324,0.000343558,0.004269391,0.0001283851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990497,0.0005623277,0.0004377862,0.0002541927,0.0001893021,0.000234639,0.0000233662,0.00001574828,0.007785635],"genre_scores_gemma":[0.9988512,0.00008570841,0.0002373355,0.0004683245,0.00005316275,0.00002853012,0.0001386708,0.00001174525,0.0001253229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008354196,"threshold_uncertainty_score":0.5424805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005873499841731589,"score_gpt":0.2482421614161834,"score_spread":0.2423686615744518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}