{"id":"W4410133395","doi":"10.3389/fphys.2025.1540400","title":"Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions","year":2025,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fondation Leducq; National Institutes of Health; Agence Nationale de la Recherche; British Heart Foundation","keywords":"Gap junction; Purkinje fibers; Modulation (music); Cardiology; Neuroscience; Medicine; Materials science; Internal medicine; Physics; Electrophysiology; Biology; Cell biology; Acoustics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567864,0.0001880653,0.0002035442,0.00009795685,0.0001364003,0.0004648006,0.0002506937,0.0002203717,0.0008232955],"category_scores_gemma":[0.0004437839,0.0001695357,0.0001899745,0.00006197823,0.0003423197,0.0003190563,0.0002815325,0.0003399628,0.00009354712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303824,"about_ca_system_score_gemma":0.000115737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002500625,"about_ca_topic_score_gemma":0.0003367601,"domain_scores_codex":[0.9999393,0.000009256249,0.000005605757,0.0000142795,0.00001078924,0.00002072634],"domain_scores_gemma":[0.9998351,0.00005591039,0.00004927223,0.00001754848,0.000009184574,0.0000329581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003820757,0.00004306519,0.002048614,0.000053575,0.00001834449,0.0001127571,0.00005856748,0.002279805,0.9931418,0.0002006662,0.00002238076,0.001638417],"study_design_scores_gemma":[0.0001601534,0.001840469,0.2030162,0.00004320767,0.0001975828,0.0008021711,0.0003346594,0.08195624,0.7091383,0.001501576,0.0009612769,0.00004808255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984168,0.0001039899,0.001298746,0.00001198097,0.000003812775,0.000003686503,0.00001529204,0.00001342862,0.0001323529],"genre_scores_gemma":[0.9995167,0.00006920834,0.0003323284,0.000004243821,0.000001252076,0.000004825081,0.00001656871,0.000003439292,0.00005139004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008232955,"threshold_uncertainty_score":0.002754152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007353009839492213,"score_gpt":0.2549833390248507,"score_spread":0.2476303291853585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}