{"id":"W4410136066","doi":"10.1007/s12325-025-03183-x","title":"One-Year Efficacy of Guselkumab Versus Advanced Therapies for the Treatment of Moderately to Severely Active Crohn’s Disease: A Network Meta-Analysis","year":2025,"lang":"en","type":"review","venue":"Advances in Therapy","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"Johnson and Johnson","keywords":"Medicine; Crohn's disease; Internal medicine; Rheumatology; Disease; Meta-analysis; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001558114,0.0005043951,0.002097312,0.0001510501,0.00007740735,0.00001407933,0.0005123491,0.0001566306,0.00003105355],"category_scores_gemma":[0.00007669612,0.0003321095,0.002760872,0.0005194414,0.0001118322,0.00001160134,0.00004534474,0.00006907953,9.715091e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007356065,"about_ca_system_score_gemma":0.0003641463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005198663,"about_ca_topic_score_gemma":0.000103742,"domain_scores_codex":[0.9978967,0.000290771,0.0006633681,0.0006313664,0.000197896,0.0003198882],"domain_scores_gemma":[0.9975392,0.0006439592,0.0005108831,0.001057577,0.0001689101,0.00007948094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02857707,0.0005739836,0.000005874909,0.001185263,0.1198353,0.000004931354,0.0001572231,0.02953223,0.000003301435,0.0002238462,0.00002137086,0.8198796],"study_design_scores_gemma":[0.00348064,0.0008481796,0.001263734,0.0003149702,0.09382194,9.044611e-8,0.00004668844,0.00001712964,0.0001552932,0.0002368471,0.8992312,0.0005832691],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000850001,0.9942491,0.0007232937,0.00002076472,0.0001665735,0.003105846,0.0008187484,0.000008402978,0.00005724383],"genre_scores_gemma":[0.001812772,0.9941364,0.001004136,0.00004136471,0.0001060065,0.002377701,0.0002700426,0.00004740814,0.0002041681],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8992099,"threshold_uncertainty_score":0.9999131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07057943722818513,"score_gpt":0.3817224484559923,"score_spread":0.3111430112278072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}