{"id":"W4410138286","doi":"10.1093/immhor/vlaf016","title":"HIV Nef disrupts Lck signaling by inducing aberrant phosphorylation of its substrates","year":2025,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; CD3; Hyperphosphorylation; T-cell receptor; Cell biology; Stimulation; Kinase; Chemistry; Tyrosine phosphorylation; Signal transduction; Molecular biology; Western blot; T cell; Biology; CD8; Immunology; Biochemistry; Endocrinology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255999,0.0001463189,0.000260036,0.0001673392,0.000130029,0.00001406285,0.0001734383,0.0001625974,0.0003567698],"category_scores_gemma":[0.0000760922,0.0001319918,0.00007253976,0.0003233122,0.00009594811,0.0000934246,0.00005142363,0.0002759081,0.0003330169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007888941,"about_ca_system_score_gemma":0.0001229716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003073982,"about_ca_topic_score_gemma":0.00003067351,"domain_scores_codex":[0.9988708,0.000124912,0.0003497459,0.0002394715,0.00004155836,0.0003735076],"domain_scores_gemma":[0.9994182,0.0002050741,0.00007444737,0.0002219266,0.00006428336,0.00001609563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414212,0.0002595946,0.01464617,0.00002963594,0.0002206412,0.000006018095,0.0003712108,0.00001316844,0.9767144,0.0009172296,0.001543941,0.005136589],"study_design_scores_gemma":[0.001865023,0.0001690743,0.02174264,0.0001973563,0.00003490949,0.000004032722,0.0004320155,0.000007357664,0.9714889,0.0002091842,0.003715345,0.0001341765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721336,0.02311462,0.00009225224,0.000264325,0.0002489423,0.000303431,0.0001299192,0.00003121229,0.003681675],"genre_scores_gemma":[0.9962395,0.0003471766,0.00003876179,0.00001000786,0.000004658395,0.0000451846,0.0003700807,0.000009161573,0.002935506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02410584,"threshold_uncertainty_score":0.538247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126349889474245,"score_gpt":0.2730887504463016,"score_spread":0.2604537614988771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}