{"id":"W4410138286","doi":"10.1093/immhor/vlaf016","title":"HIV Nef disrupts Lck signaling by inducing aberrant phosphorylation of its substrates","year":2025,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; CD3; Hyperphosphorylation; T-cell receptor; Cell biology; Stimulation; Kinase; Chemistry; Tyrosine phosphorylation; Signal transduction; Molecular biology; Western blot; T cell; Biology; CD8; Immunology; Biochemistry; Endocrinology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001015758,0.00028565,0.0001602303,0.0001738492,0.0001289734,0.0002485349,0.0002073895,0.0002963532,0.0008413201],"category_scores_gemma":[0.00008897811,0.0001292469,0.0001831611,0.0001106133,0.0001900678,0.000131719,0.0001381791,0.0005341728,0.0002174967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837432,"about_ca_system_score_gemma":0.0001267642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006098066,"about_ca_topic_score_gemma":0.0007733782,"domain_scores_codex":[0.9998699,0.00002469174,0.00001513849,0.00002297451,0.00002265971,0.00004460722],"domain_scores_gemma":[0.999908,0.00003043346,0.00001771154,0.00001453113,0.000004551025,0.00002473077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009949512,0.00004278154,0.00007355617,0.00001577758,0.000002411172,0.00005031628,0.000007337901,0.00003382217,0.9991866,0.00008420711,0.00001584061,0.0003879794],"study_design_scores_gemma":[0.00001104652,0.0001636443,0.00148018,0.000003042749,0.000004921923,0.0001621672,0.00000983216,0.0005019699,0.9969968,0.00002848894,0.0006362214,0.000001742633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977978,0.0004535831,0.000679453,0.00003478717,0.00001491018,0.00001274063,0.000201607,0.00003313722,0.0007720879],"genre_scores_gemma":[0.9969579,0.0004198718,0.00102044,0.00002642751,0.000006136864,0.00002554131,0.0002580605,0.0000151388,0.001270323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008413201,"threshold_uncertainty_score":0.002814472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126349889474245,"score_gpt":0.2730887504463016,"score_spread":0.2604537614988771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}