{"id":"W4410138345","doi":"10.1021/acs.orglett.5c01274","title":"Peunipyrone A, an Unexpected Highly Oxygenated γ-Pyrone with a 6/6/6/6/6 Pentacyclic Ring System from a Sponge-Derived Fungus <i>Aspergillus peuniceus</i>","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Sponge; Pyrone; Chemistry; Fungus; Ring (chemistry); Stereochemistry; Aspergillus; Organic chemistry; Microbiology; Botany; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004859228,0.0002776617,0.0001094224,0.0002649773,0.0001106523,0.0001869066,0.0001148474,0.0001626142,0.0009271937],"category_scores_gemma":[0.00008330819,0.00008255539,0.0001241701,0.0001745563,0.0001657044,0.0002834577,0.000208862,0.0003343503,0.0002274893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000858241,"about_ca_system_score_gemma":0.000159754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532491,"about_ca_topic_score_gemma":0.0002729011,"domain_scores_codex":[0.9999706,0.000005231027,0.000002377838,0.00000813221,0.000006994695,0.000006720488],"domain_scores_gemma":[0.999958,0.000006247698,0.00001017093,0.000005844225,0.000004030687,0.00001566132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001668346,0.00004041012,0.0004488211,0.0001823054,0.00001142231,0.0007044992,0.00004493922,0.0003955123,0.9857703,0.000391503,0.0001007745,0.01174262],"study_design_scores_gemma":[0.00004813066,0.001428411,0.008681379,0.0000305842,0.00005089354,0.003103276,0.00008657018,0.0007451278,0.9671669,0.0006728639,0.01795695,0.00002901063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793747,0.006424969,0.006616988,0.0001491351,0.00005943641,0.00006956205,0.0009344036,0.00009772603,0.00627296],"genre_scores_gemma":[0.9924501,0.002234192,0.002925749,0.00005659125,0.00001408222,0.00001345235,0.000502724,0.000006758242,0.001796379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009271937,"threshold_uncertainty_score":0.003101707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006453233746912318,"score_gpt":0.2041305806657949,"score_spread":0.1976773469188826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}