{"id":"W4410141208","doi":"10.1101/2025.05.06.25327023","title":"The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) longitudinal study protocol: Phase 4 (“Enrichment”) and Phase 5 (“Rescan”)","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Frailty in Older Adults","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Medical Research Council; Directorate for Biological Sciences; European Commission; Biotechnology and Biological Sciences Research Council; Guarantors of Brain; National Institute for Health and Care Research; NIHR Cambridge Biomedical Research Centre; Wellcome Trust","keywords":"Ageing; Phase (matter); Neuroscience; Psychology; Protocol (science); Computational neuroscience; Cognitive science; Medicine; Physics; Internal medicine; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03288955,0.002880074,0.004777142,0.001990338,0.004880146,0.003157884,0.003108908,0.00445117,0.1044686],"category_scores_gemma":[0.04890293,0.00297494,0.002011092,0.001832676,0.001779564,0.002724069,0.0033438,0.004141171,0.03530036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004748259,"about_ca_system_score_gemma":0.01777033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0114819,"about_ca_topic_score_gemma":0.03024556,"domain_scores_codex":[0.989738,0.005360577,0.001333572,0.001300613,0.00133128,0.0009359089],"domain_scores_gemma":[0.9687657,0.005419658,0.002583859,0.005770245,0.0147902,0.002670337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.1267678,0.01008625,0.01107844,0.01581506,0.0005829464,0.0006493315,0.004053449,0.002187491,0.003003341,0.01680536,0.6979988,0.1109716],"study_design_scores_gemma":[0.1092759,0.01974002,0.1222073,0.01790339,0.000918884,0.0005304209,0.002034352,0.003300427,0.004076753,0.02363798,0.695601,0.0007736048],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.008006602,0.0007032641,0.006984491,0.001081555,0.0007705533,0.9502945,0.02512336,0.0005085731,0.006527015],"genre_scores_gemma":[0.002787974,0.0000801625,0.002949135,0.0002990743,0.00005448776,0.990281,0.002397985,0.00002945812,0.001120768],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1044686,"threshold_uncertainty_score":0.3494821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0572454726470044,"score_gpt":0.389709422740502,"score_spread":0.3324639500934976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}