{"id":"W4410156410","doi":"10.1001/jamasurg.2025.1072","title":"Breast Tumor-Bed Biopsy for Pathological Complete Response Prediction","year":2025,"lang":"en","type":"letter","venue":"JAMA Surgery","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute","keywords":"Medicine; Biopsy; Breast cancer; Mammography; Neoadjuvant therapy; Ductal carcinoma; Magnetic resonance imaging; Radiology; Breast surgery; Cancer; Breast-conserving surgery; Surgery; Internal medicine; Mastectomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003672341,0.0004664093,0.0007252109,0.0006022701,0.00023471,0.0004063462,0.0004520751,0.0004180167,0.003627352],"category_scores_gemma":[0.003161341,0.0002823225,0.000444155,0.0003496504,0.0002862099,0.000439213,0.0002791167,0.0004467304,0.0007740721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754324,"about_ca_system_score_gemma":0.0007179326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004089366,"about_ca_topic_score_gemma":0.001213208,"domain_scores_codex":[0.9983749,0.0009685355,0.0001247445,0.0001930951,0.0002715106,0.00006721232],"domain_scores_gemma":[0.9977949,0.0005720522,0.0007317095,0.0002397023,0.0003307841,0.0003308627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07881403,0.003275072,0.672147,0.0008012135,0.000613165,0.0004217696,0.0001255846,0.002678163,0.02633471,0.0004296504,0.004601669,0.2097581],"study_design_scores_gemma":[0.01065555,0.06377622,0.8679863,0.0003439716,0.0009424291,0.002545856,0.0001325487,0.01931766,0.0196219,0.0009797632,0.01361737,0.00008055705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633594,0.00622117,0.01257941,0.0004839971,0.0002818307,0.006122021,0.001893528,0.0002676248,0.008791137],"genre_scores_gemma":[0.9860758,0.000615455,0.009324342,0.0002854469,0.00007903657,0.001676262,0.0007714038,0.00001710026,0.001155186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003672341,"threshold_uncertainty_score":0.01942146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02276748475479353,"score_gpt":0.2509548567902659,"score_spread":0.2281873720354723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}