{"id":"W4410156410","doi":"10.1001/jamasurg.2025.1072","title":"Breast Tumor-Bed Biopsy for Pathological Complete Response Prediction","year":2025,"lang":"en","type":"letter","venue":"JAMA Surgery","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute","keywords":"Medicine; Biopsy; Breast cancer; Mammography; Neoadjuvant therapy; Ductal carcinoma; Magnetic resonance imaging; Radiology; Breast surgery; Cancer; Breast-conserving surgery; Surgery; Internal medicine; Mastectomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004453874,0.0004406287,0.0005965549,0.0001613758,0.0001679262,0.00005384782,0.000189137,0.000852074,0.00002398996],"category_scores_gemma":[0.0003874737,0.0003919393,0.0005322331,0.0001266723,0.0001629099,0.000003995071,0.000176392,0.0004020505,0.00001187501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000861152,"about_ca_system_score_gemma":0.0002552638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002201771,"about_ca_topic_score_gemma":0.000001494289,"domain_scores_codex":[0.997734,0.0003223529,0.0004127891,0.0008266812,0.0002014163,0.0005027892],"domain_scores_gemma":[0.9982547,0.0006868581,0.0002183004,0.0005827036,0.0002093394,0.00004805262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00255567,0.00005152329,0.004527234,0.0001327787,0.0002974113,0.0002584917,0.000007582556,7.136737e-7,0.003932367,0.000001742678,0.9865209,0.00171359],"study_design_scores_gemma":[0.0006694603,0.00007024028,0.05406488,0.0001562422,0.00015243,0.0007793984,0.00001289208,0.000003723683,0.0009248661,0.00004528847,0.9427239,0.0003966611],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1039872,0.001760263,0.0008806771,0.8589395,0.003830649,0.001222414,0.02866389,0.0002184381,0.0004970446],"genre_scores_gemma":[0.09998491,0.0004061064,0.00119059,0.8261744,0.0226628,0.002832782,0.03989245,0.0002505466,0.006605387],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04953765,"threshold_uncertainty_score":0.9998533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02276748475479353,"score_gpt":0.2509548567902659,"score_spread":0.2281873720354723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}