{"id":"W4410158118","doi":"10.1016/j.xcrm.2025.102126","title":"RSPO1, a potent inducer of pancreatic β cell neogenesis","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Fondation Générale de Santé; Fondation Schlumberger pour l’Education et la Recherche; Max-Planck-Gesellschaft; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; H2020 European Research Council; Juvenile Diabetes Research Foundation United States of America; Juvenile Diabetes Research Foundation Canada; Agence Nationale de la Recherche; Bundesministerium für Bildung und Forschung","keywords":"Neogenesis; Inducer; Biology; Cell biology; Internal medicine; Endocrinology; Medicine; Genetics; Diabetes mellitus; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102643,0.0002876763,0.000164588,0.0002775899,0.00009410183,0.0002029256,0.0001192058,0.0002501918,0.001415952],"category_scores_gemma":[0.0000873501,0.00008061517,0.0001955119,0.0001541384,0.0001516405,0.0002139802,0.0001770564,0.0006172183,0.000339416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001123085,"about_ca_system_score_gemma":0.0001451332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000904379,"about_ca_topic_score_gemma":0.0001870296,"domain_scores_codex":[0.9999454,0.000009711105,0.000003815511,0.0000125853,0.00001804765,0.0000105302],"domain_scores_gemma":[0.9999412,0.00001466836,0.00001531068,0.000007659341,0.000004370017,0.0000168155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008171691,0.00004791509,0.0001180437,0.00007743697,0.000004237083,0.00005570357,0.000009193855,0.00008997764,0.9952033,0.0001958172,0.00007676829,0.004039783],"study_design_scores_gemma":[0.0000115411,0.000276187,0.0009499762,0.000004810313,0.000009030149,0.0001552383,0.000007934884,0.0001650595,0.9927641,0.00004178534,0.005611824,0.000002504083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724547,0.008613498,0.01046628,0.0002850996,0.00009282961,0.0001035557,0.0007788822,0.0001445315,0.00706068],"genre_scores_gemma":[0.9799063,0.006372155,0.007221272,0.0001340814,0.00004462696,0.0000730625,0.0009588323,0.000034208,0.005255417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001415952,"threshold_uncertainty_score":0.004736781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183352590952217,"score_gpt":0.2530941073735604,"score_spread":0.2412605814640383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}