{"id":"W4410158118","doi":"10.1016/j.xcrm.2025.102126","title":"RSPO1, a potent inducer of pancreatic β cell neogenesis","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Fondation Générale de Santé; Fondation Schlumberger pour l’Education et la Recherche; Max-Planck-Gesellschaft; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; H2020 European Research Council; Juvenile Diabetes Research Foundation United States of America; Juvenile Diabetes Research Foundation Canada; Agence Nationale de la Recherche; Bundesministerium für Bildung und Forschung","keywords":"Neogenesis; Inducer; Biology; Cell biology; Internal medicine; Endocrinology; Medicine; Genetics; Diabetes mellitus; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004540141,0.0002156132,0.0007879768,0.0003394107,0.00004831043,0.000003541494,0.00005760685,0.0001300038,0.001056375],"category_scores_gemma":[0.0005983496,0.0001544838,0.0001293804,0.0005455425,0.0001775712,0.00002937855,0.00003912899,0.0001516911,0.00001848952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007157632,"about_ca_system_score_gemma":0.000315671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000173482,"about_ca_topic_score_gemma":6.841501e-7,"domain_scores_codex":[0.9980705,0.00003782194,0.0008359203,0.0003681598,0.0004220574,0.0002654972],"domain_scores_gemma":[0.9983085,0.0001753703,0.0003327781,0.0007202443,0.0002464075,0.0002167249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003034414,0.0009134421,0.2112214,0.00259542,0.0002771693,0.001268335,0.0006572492,0.00001456141,0.6896777,0.0001072832,0.08160792,0.01135606],"study_design_scores_gemma":[0.005301445,0.001050737,0.0968006,0.002068374,0.002882612,0.0002930709,0.001747745,0.0001409336,0.7944531,0.0004833834,0.09443969,0.0003382481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6920589,0.004613509,0.0002716545,0.001129946,0.0007037456,0.0003718122,8.832955e-7,0.00006242321,0.3007871],"genre_scores_gemma":[0.9439215,0.0002855192,0.0003907762,0.001543437,0.0001675828,0.00002748024,0.00003243624,0.00001994686,0.05361134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2518626,"threshold_uncertainty_score":0.9998568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183352590952217,"score_gpt":0.2530941073735604,"score_spread":0.2412605814640383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}