{"id":"W4410165574","doi":"10.1136/bmjonc-2025-000766","title":"Disease-free survival as a surrogate for overall survival in early-stage pancreatic cancer trials: a correlation meta-analysis","year":2025,"lang":"en","type":"article","venue":"BMJ Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; BC Cancer Agency; Dr. Georges-L.-Dumont University Hospital Centre; Princess Margaret Cancer Centre","funders":"Government of Ontario","keywords":"Medicine; Surrogate endpoint; Distributed File System; Internal medicine; Oncology; Stage (stratigraphy); Meta-analysis; Clinical trial; Pancreatic cancer; Neoadjuvant therapy; Randomized controlled trial; Adjuvant therapy; Cancer; Breast cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1132722,0.003159576,0.01612718,0.005529063,0.0005904892,0.004453318,0.002467591,0.002356994,0.002873155],"category_scores_gemma":[0.2070203,0.001759397,0.05504714,0.007831912,0.00110192,0.002991516,0.002212062,0.003327956,0.0004085032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002232003,"about_ca_system_score_gemma":0.002796805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002262218,"about_ca_topic_score_gemma":0.003359224,"domain_scores_codex":[0.847734,0.1236834,0.01589193,0.00603653,0.005734058,0.0009201927],"domain_scores_gemma":[0.7479366,0.2154948,0.02077838,0.009356137,0.005592407,0.0008416187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004005498,0.00002703144,0.01155494,0.05913261,0.9167901,0.0000759305,0.00005615823,0.001810659,0.0001232815,0.0003215505,0.0004806286,0.005621694],"study_design_scores_gemma":[0.001785717,0.0005036432,0.005735253,0.006888269,0.9808976,0.00009371238,0.00002679763,0.001933641,0.0001481687,0.0009094765,0.001044392,0.00003319433],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02576029,0.9522594,0.01576089,0.0009620119,0.0006440442,0.001872043,0.001460287,0.0001591316,0.001121962],"genre_scores_gemma":[0.7900124,0.1745955,0.02127612,0.002430961,0.0008408718,0.007764558,0.001980437,0.000180579,0.0009184413],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1132722,"threshold_uncertainty_score":0.5990477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2264306928772775,"score_gpt":0.4999194906153062,"score_spread":0.2734887977380288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}