{"id":"W4410168924","doi":"10.1093/eurheartj/ehaf314","title":"Clinical staging to guide management of metabolic disorders and their sequelae: a European Atherosclerosis Society consensus statement","year":2025,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Diet and metabolism studies","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; Hamilton Health Sciences; Ted Rogers Centre for Heart Research; McMaster University; Population Health Research Institute","funders":"Daiichi Sankyo Europe; Duke Clinical Research Institute; National Heart, Lung, and Blood Institute; Belvoir Media Group; Biomedical Research Council; Medical Research Council; Canadian Institutes of Health Research; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Silence Therapeutics; Fondation Leducq; Türk Kardiyoloji Derneği; Idorsia Pharmaceuticals; European Association for the Study of Diabetes; Imperial College London; University of Toronto; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ultragenyx Pharmaceutical; ZonMw; University College London; HLS Therapeutics; Novo Nordisk; MyoKardia; Ironwood Pharmaceuticals, Incorporated; Medicines Company; Alnylam Pharmaceuticals; AstraZeneca; Amarin Corporation; American Heart Association; Moderna; Tillotts Pharma; American Society of Nephrology; Universiteit Maastricht; Boston Scientific Corporation; Hellenic Atherosclerosis Society; National Medical Research Council; Amryt Pharma; Kowa Company; Esperion Therapeutics; Cytokinetics; Brigham and Women's Hospital; Pfizer; Amgen; Sanofi; European Atherosclerosis Society; Abbott Laboratories; CSL Behring; Bristol-Myers Squibb; Eli Lilly and Company; Regeneron Pharmaceuticals","keywords":"Medicine; Consensus conference; Statement (logic); Intensive care medicine; Internal medicine; Law","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003475632,0.0002096789,0.0005250244,0.00009928723,0.0002151054,0.00004983463,0.0001181054,0.00001535626,0.00002625225],"category_scores_gemma":[0.0000693006,0.0001538481,0.0003105705,0.0002207658,0.0001620673,0.00003486302,0.0003453833,0.000310408,0.0000257457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002141573,"about_ca_system_score_gemma":0.0000503265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005102718,"about_ca_topic_score_gemma":0.000001465835,"domain_scores_codex":[0.997768,0.0005675346,0.0008329067,0.0002885967,0.0002117317,0.0003311967],"domain_scores_gemma":[0.9991359,0.00008025519,0.0001575195,0.0002704041,0.0001158531,0.0002400327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002692535,0.0006117516,0.4339547,0.0004163291,0.003853319,0.00007607775,0.007162909,0.00002720352,0.004289845,0.001547404,0.2565283,0.291263],"study_design_scores_gemma":[0.001308655,0.00009590757,0.5352295,0.0003192615,0.0001826856,0.000007057279,0.002540893,0.000008036996,0.00006256957,0.00002344076,0.4601395,0.00008243402],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9134654,0.004640355,0.001470297,0.006835074,0.0007125944,0.0004491095,0.00001353616,0.00004870534,0.07236491],"genre_scores_gemma":[0.9510808,0.02115092,0.01678284,0.004129525,0.0002836702,0.000003132942,0.000002087902,0.00006035766,0.006506676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2911806,"threshold_uncertainty_score":0.6273744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06032554542837898,"score_gpt":0.3689459678853897,"score_spread":0.3086204224570107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}