{"id":"W4410169683","doi":"10.1111/aas.70044","title":"Adaptations and Heterogeneity of Treatment Effects in Platform Trials—Protocol for Two Methodological Studies","year":2025,"lang":"en","type":"article","venue":"Acta Anaesthesiologica Scandinavica","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Protocol (science); Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2201178,0.006886154,0.01088982,0.007958038,0.003930685,0.006905224,0.00483308,0.01460077,0.04367572],"category_scores_gemma":[0.3900573,0.004810515,0.01793067,0.008716393,0.006579142,0.005348012,0.005578026,0.01116785,0.009170021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01047319,"about_ca_system_score_gemma":0.02501515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001678797,"about_ca_topic_score_gemma":0.002120581,"domain_scores_codex":[0.7381703,0.1681253,0.06470747,0.008968964,0.01584522,0.004182837],"domain_scores_gemma":[0.7190119,0.1514551,0.0436199,0.04574547,0.03651302,0.003654594],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.1418528,0.003885827,0.003774449,0.4389256,0.02000915,0.001748636,0.007896574,0.008387997,0.005764915,0.0752174,0.1200216,0.172515],"study_design_scores_gemma":[0.2873237,0.01561373,0.009667112,0.1650188,0.01549372,0.001103338,0.001622027,0.01883155,0.009631611,0.1131779,0.3612164,0.001300182],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0003430889,0.0003972362,0.005890444,0.0002883166,0.0004633533,0.9914243,0.0007350906,0.00008464699,0.0003734296],"genre_scores_gemma":[0.0003115255,0.00007833361,0.005521464,0.00009530476,0.00001801046,0.9938173,0.0000640655,0.00000485593,0.00008926845],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.7798822,"threshold_uncertainty_score":0.9617336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8515623628999941,"score_gpt":0.6733801112062644,"score_spread":0.1781822516937297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}