{"id":"W4410186945","doi":"10.1136/jitc-2024-010073","title":"BCL-2 mutant B7H6-CAR-T cells synergized with venetoclax for treating small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario College of Art and Design","funders":"China Postdoctoral Science Foundation; Ministry of Education; National Natural Science Foundation of China","keywords":"Venetoclax; Cancer research; Chimeric antigen receptor; Antigen; In vivo; Medicine; In vitro; Cancer; Immunology; Immunotherapy; Biology; Leukemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629637,0.0003593682,0.0004357938,0.0003074012,0.0001554472,0.0002127991,0.0002653998,0.0002742538,0.001262272],"category_scores_gemma":[0.00007647729,0.0001046319,0.0003056821,0.0002270754,0.0001933407,0.0001923654,0.0001573209,0.0006802707,0.000230172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001953272,"about_ca_system_score_gemma":0.0003837375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006348151,"about_ca_topic_score_gemma":0.001154499,"domain_scores_codex":[0.9999052,0.00001922318,0.00000643254,0.00001494467,0.00002356444,0.0000305344],"domain_scores_gemma":[0.999936,0.00001365938,0.00001126797,0.000007368069,0.000005509206,0.00002620491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001700299,0.00114797,0.0009831735,0.0002176663,0.00004972579,0.0001360449,0.00004593112,0.0008282062,0.9740604,0.0001682728,0.0005056957,0.02015667],"study_design_scores_gemma":[0.0007696318,0.01684356,0.009787343,0.00001991196,0.000231969,0.0009022913,0.00004758082,0.004344671,0.9599555,0.00007914758,0.007003372,0.00001511384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942173,0.002377882,0.0009140706,0.00009599199,0.00005602336,0.0001157344,0.000158449,0.0001302854,0.001934241],"genre_scores_gemma":[0.9972354,0.0008530878,0.000737205,0.00002895894,0.00002206772,0.00005063603,0.0002482051,0.000007528621,0.0008169528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262272,"threshold_uncertainty_score":0.004222751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716655082443336,"score_gpt":0.350663301073179,"score_spread":0.3334967502487456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}