{"id":"W4410189669","doi":"10.1002/em.70011","title":"Adverse Outcome Pathway‐Informed Integrated Testing to Identify Chemicals Causing Genotoxicity Through Oxidative <scp>DNA</scp> Damage: Case Study on 4‐Nitroquinoline 1‐Oxide","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; Health Canada","funders":"Health Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"DNA damage; Genotoxicity; DNA repair; DNA; Oxidative phosphorylation; Micronucleus test; Oxidative damage; Mutation; Mutagenesis; Oxidative stress; Genetics; Mutation frequency; Biology; Micronucleus; Molecular biology; Biochemistry; Chemistry; Gene; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003128084,0.0006443372,0.0006956228,0.001002797,0.0006887032,0.0009392505,0.0008201282,0.001878137,0.001005761],"category_scores_gemma":[0.002478236,0.0002916435,0.0009671615,0.0006096399,0.0009179622,0.0006053746,0.001087399,0.0009150395,0.0002441932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001186282,"about_ca_system_score_gemma":0.0009812425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003275552,"about_ca_topic_score_gemma":0.006453362,"domain_scores_codex":[0.9984503,0.0004138382,0.00009353968,0.0002627291,0.0006415417,0.0001380084],"domain_scores_gemma":[0.9981247,0.000657611,0.0004181979,0.0001749159,0.0004945834,0.0001299411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001760296,0.002100756,0.1114573,0.00128473,0.0002392728,0.02901183,0.002127644,0.01913325,0.7048154,0.002519179,0.001207395,0.1243429],"study_design_scores_gemma":[0.0001218261,0.009365721,0.04356214,0.0001562799,0.0004471072,0.02296246,0.001624494,0.03184204,0.8694091,0.003660857,0.01668424,0.0001637509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383143,0.001567896,0.05291545,0.00127384,0.00004388368,0.001099093,0.0005986883,0.0002929142,0.003893977],"genre_scores_gemma":[0.938212,0.001411072,0.05612386,0.0004900252,0.00002593787,0.0002361149,0.0003138969,0.00006646881,0.00312068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003275552,"threshold_uncertainty_score":0.01654309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02227394238857269,"score_gpt":0.3092386908703414,"score_spread":0.2869647484817687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}