{"id":"W4410191339","doi":"10.1128/jvi.00151-25","title":"Adaptive selection of quasispecies during <i>in vivo</i> passaging in chickens, mice, and ferrets results in host-specific strains for the H9N2 avian influenza virus","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada; University of Toronto","funders":"Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center); Department of Education of Guangdong Province; National Natural Science Foundation of China","keywords":"Biology; Viral quasispecies; Virology; Virus; Viral evolution; Mutant; Gene; Host adaptation; Titer; Virulence; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003060855,0.0003624239,0.000212102,0.0002114914,0.0001931017,0.0002715222,0.0002226257,0.0002804596,0.0006803024],"category_scores_gemma":[0.0001893542,0.0001370979,0.0003355705,0.00005611991,0.0002116219,0.0001714249,0.0001747228,0.0004738222,0.0002049573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465702,"about_ca_system_score_gemma":0.00009008758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005771308,"about_ca_topic_score_gemma":0.0008800091,"domain_scores_codex":[0.99976,0.00004995708,0.00001885768,0.00006990485,0.00003517961,0.00006618976],"domain_scores_gemma":[0.9997754,0.00003600553,0.00007760806,0.00002989887,0.0000229636,0.00005819814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008307482,0.00002808128,0.0006855869,0.000006938622,0.000004895381,0.00002041248,0.00001760566,0.00001890211,0.9987926,0.00002379273,0.000009018086,0.0003090132],"study_design_scores_gemma":[0.00002979564,0.003075883,0.05078091,0.00001137056,0.00005631927,0.0008499615,0.0001418291,0.001199636,0.942604,0.00005721883,0.001178786,0.000014414],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987041,0.0001384655,0.0007121777,0.00002267994,0.000008907677,0.00002224817,0.000081313,0.00002155797,0.0002886171],"genre_scores_gemma":[0.9978918,0.00008934658,0.0008812664,0.00004255714,0.000008645256,0.00003353483,0.0002857638,0.000022424,0.000744692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006803024,"threshold_uncertainty_score":0.002275825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05389399630058534,"score_gpt":0.3561510807391421,"score_spread":0.3022570844385568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}