{"id":"W4410192422","doi":"10.1158/2643-3230.bcd-24-0240","title":"DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC; Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"NHLBI Division of Intramural Research; National Cancer Institute; Canadian Institutes of Health Research; Pharmacyclics; EUSA Pharma; National Institute of Allergy and Infectious Diseases; MorphoSys; Terry Fox Research Institute; Michael Smith Health Research BC; Ministerio de Ciencia e Innovación; Canada's Michael Smith Genome Sciences Centre; Fundación Cellex; St. Jude Children's Research Hospital; Gilead Sciences; TG Therapeutics; Pfizer; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Amgen; Incyte; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"DNA methylation; Lymphoma; DNA; Burkitt's lymphoma; Methylation; Cancer research; Computational biology; Biology; Medicine; Genetics; Immunology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008235104,0.000132174,0.0003487129,0.00005597655,0.00003301354,0.00002316769,0.00003956512,0.00006931493,0.000008455368],"category_scores_gemma":[0.0000416377,0.000088204,0.00009313864,0.0001467393,0.0001167888,0.00007856635,0.00003735603,0.00003803485,4.487238e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004858267,"about_ca_system_score_gemma":0.0002834638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005737898,"about_ca_topic_score_gemma":0.0002250239,"domain_scores_codex":[0.9991872,0.00003786492,0.0002251933,0.0002665012,0.0001612029,0.000121979],"domain_scores_gemma":[0.999459,0.0001157083,0.00009158246,0.0002240171,0.0000532352,0.0000564413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007033987,0.001300439,0.9233827,0.0002325871,0.001662911,0.0000952035,0.00004339679,0.000005258886,0.00162056,0.002447918,0.0005180342,0.06798762],"study_design_scores_gemma":[0.005215677,0.0004133847,0.8888389,0.0003943469,0.001725026,0.0000114811,0.00002830687,0.000004220371,0.1024276,0.0001821332,0.0006747892,0.00008408402],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893723,0.007091542,0.0000717751,0.001156842,0.0000945373,0.0002682077,0.00004132851,0.00001696905,0.001886515],"genre_scores_gemma":[0.997862,0.0008903694,0.0001766624,0.0004283114,0.0000519559,0.00005317335,0.00002353406,0.00001007421,0.0005039116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1008071,"threshold_uncertainty_score":0.3596855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009172808857633568,"score_gpt":0.3035139083737359,"score_spread":0.2943410995161023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}