{"id":"W4410192422","doi":"10.1158/2643-3230.bcd-24-0240","title":"DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features","year":2025,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC; Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"NHLBI Division of Intramural Research; National Cancer Institute; Canadian Institutes of Health Research; Pharmacyclics; EUSA Pharma; National Institute of Allergy and Infectious Diseases; MorphoSys; Terry Fox Research Institute; Michael Smith Health Research BC; Ministerio de Ciencia e Innovación; Canada's Michael Smith Genome Sciences Centre; Fundación Cellex; St. Jude Children's Research Hospital; Gilead Sciences; TG Therapeutics; Pfizer; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Amgen; Incyte; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"DNA methylation; Lymphoma; DNA; Burkitt's lymphoma; Methylation; Cancer research; Computational biology; Biology; Medicine; Genetics; Immunology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338133,0.0001772761,0.0002176552,0.0007043928,0.0002249511,0.0003339769,0.0001262626,0.0001895923,0.001429543],"category_scores_gemma":[0.001014472,0.00011697,0.0001575369,0.0005091762,0.0002553767,0.0002061571,0.0005226401,0.0001872898,0.0001588528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729552,"about_ca_system_score_gemma":0.0001183914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342051,"about_ca_topic_score_gemma":0.002057436,"domain_scores_codex":[0.9998477,0.00003897108,0.00001906339,0.00003905025,0.00002367433,0.00003155053],"domain_scores_gemma":[0.9995748,0.00009559271,0.0001879732,0.00005147352,0.00004713652,0.00004292079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004059524,0.00001290684,0.9631413,0.00002453656,0.00005221841,0.0003623276,0.0002635791,0.0001271663,0.0264285,0.00009333374,0.00007311659,0.009015032],"study_design_scores_gemma":[0.00001054837,0.000100945,0.9942617,0.000008116284,0.00003475426,0.002730401,0.0003735175,0.000387047,0.001453364,0.0002469157,0.0003869741,0.000005758046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991303,0.0001693158,0.0002551135,0.00001713449,9.346254e-7,0.000007205196,0.000117824,0.000005676318,0.0002964087],"genre_scores_gemma":[0.9994998,0.00004817604,0.000164461,0.00001145795,0.000001967087,0.000005193935,0.0001814334,0.000002202321,0.00008523017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429543,"threshold_uncertainty_score":0.004782259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009172808857633568,"score_gpt":0.3035139083737359,"score_spread":0.2943410995161023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}