{"id":"W4410192683","doi":"10.1038/s41467-025-59279-z","title":"Zanidatamab monotherapy or combined with chemotherapy in HER2-expressing gastroesophageal adenocarcinoma: a phase 1 trial","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital","funders":"Jazz Pharmaceuticals","keywords":"Chemotherapy; Adenocarcinoma; Internal medicine; Gastroesophageal Junction; Medicine; Oncology; Esophageal adenocarcinoma; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892057,0.0001906774,0.0003823873,0.0003307209,0.0001491584,0.000055407,0.0006210252,0.0001605217,0.00009174693],"category_scores_gemma":[0.00005799565,0.0001410879,0.00007673116,0.000913438,0.0001208006,0.0001111009,0.0001261402,0.0008609695,0.000003127745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511879,"about_ca_system_score_gemma":0.0002300817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004383839,"about_ca_topic_score_gemma":0.0004678115,"domain_scores_codex":[0.9989085,0.00008933317,0.0003167163,0.0002537354,0.0001928581,0.0002388896],"domain_scores_gemma":[0.9979407,0.000148494,0.000104706,0.001669841,0.00007761795,0.00005863419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.562929,0.01203494,0.2736555,0.0002834002,0.001310884,0.0001818217,0.002044702,0.00001614214,0.001180031,0.01225806,0.060109,0.07399643],"study_design_scores_gemma":[0.658824,0.004078751,0.2349777,0.0006227442,0.0004076945,0.00002235523,0.000790136,0.001540316,0.0007078865,0.0002003353,0.09741694,0.0004111635],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8812808,0.01315801,0.001867363,0.08519139,0.0005176243,0.006028227,0.00004121891,0.0004188671,0.01149644],"genre_scores_gemma":[0.9851206,0.0005377707,0.008665076,0.00333374,0.00006387431,0.000131912,0.0001389388,0.00002464021,0.001983462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1038397,"threshold_uncertainty_score":0.5753397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488583350031752,"score_gpt":0.3553876119133532,"score_spread":0.3305017784130356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}