{"id":"W4410194398","doi":"10.1016/j.ijpharm.2025.125662","title":"Thermostabilization of a model viral-vectored oral thin film vaccine","year":2025,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Brockhouse Institute for Materials Research; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Virology; Medicine; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055914,0.000338655,0.0002754574,0.0001814043,0.0001180127,0.0002808539,0.0001950888,0.0002222688,0.0005278838],"category_scores_gemma":[0.0001944008,0.000109356,0.0002738161,0.0001288843,0.000125733,0.0001768928,0.0001097542,0.0003444576,0.0001190016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003311072,"about_ca_system_score_gemma":0.00020832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132323,"about_ca_topic_score_gemma":0.001334163,"domain_scores_codex":[0.9998887,0.00001677681,0.00001058298,0.00002625768,0.00003708825,0.00002061125],"domain_scores_gemma":[0.9999344,0.00001456944,0.00002090034,0.000006491929,0.00001579042,0.000007913764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001853162,0.00001230977,0.00004515226,0.00002143866,0.000002074264,0.00001144044,0.000007700509,0.0001474411,0.9989183,0.00001339762,0.000006573078,0.0007956186],"study_design_scores_gemma":[0.000001802556,0.0001964685,0.000375994,0.000002672419,0.000006992374,0.00002781949,0.000008076175,0.0007226159,0.9981849,0.000005275213,0.0004651404,0.000002214256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935917,0.0007737342,0.004904653,0.00002677936,0.00002137164,0.00007299524,0.0001739645,0.00003659516,0.0003981547],"genre_scores_gemma":[0.9834861,0.001126253,0.0135233,0.00002109279,0.000008391204,0.00008314068,0.0002599551,0.00002149482,0.00147014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132323,"threshold_uncertainty_score":0.002631068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02849182420070284,"score_gpt":0.3708746564245389,"score_spread":0.342382832223836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}