{"id":"W4410197066","doi":"10.1016/j.mtbio.2025.101841","title":"Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment","year":2025,"lang":"en","type":"article","venue":"Materials Today Bio","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Natural Science Foundation of China","keywords":"Nanocarriers; Chlorogenic acid; Chemistry; In vivo; Bioavailability; Downregulation and upregulation; Conjugated system; In vitro; Chelation; Small interfering RNA; Pharmacology; Antioxidant; Nanomedicine; Biochemistry; Biophysics; Nanotechnology; Transfection; Materials science; Polymer; Biology; Drug delivery; Nanoparticle; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326795,0.0001969881,0.0001721336,0.0002186024,0.00009848679,0.0001565116,0.0001509115,0.0002739998,0.000542255],"category_scores_gemma":[0.00007688202,0.00006535841,0.000171303,0.00008175801,0.0001534907,0.0001780364,0.000168162,0.0002330332,0.0002013395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229603,"about_ca_system_score_gemma":0.0001666215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006182698,"about_ca_topic_score_gemma":0.001056678,"domain_scores_codex":[0.9999471,0.00001124058,0.00000356113,0.00001000141,0.00001571646,0.00001242722],"domain_scores_gemma":[0.9999628,0.000005740646,0.00001118697,0.00000296382,0.000009356553,0.000007948297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009310326,0.00001898045,0.00009493883,0.00008308184,0.00000859692,0.00005622692,0.00001347687,0.0002145546,0.994152,0.0002005073,0.00009152461,0.004972855],"study_design_scores_gemma":[0.00002604641,0.0004113916,0.0007558113,0.0000111855,0.00003456926,0.0003600675,0.00001691609,0.002326025,0.9888656,0.00006438481,0.00711756,0.00001044875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9382925,0.02513796,0.03117329,0.0005145148,0.00008568216,0.0001709381,0.000210251,0.0002627413,0.004152102],"genre_scores_gemma":[0.9794579,0.004466114,0.01432417,0.0001672539,0.00002521662,0.00004784821,0.00008842546,0.00001147014,0.001411623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006182698,"threshold_uncertainty_score":0.001814008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260831250032209,"score_gpt":0.3173988009160518,"score_spread":0.2913156759128309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}