{"id":"W4410202499","doi":"10.7202/1117873ar","title":"Human Genome Editing and Sickle Cell Disease in Canada: Urgent and Unresolved Ethical Considerations","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Bioethics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University","funders":"Social Sciences and Humanities Research Council of Canada","keywords":"Disease; Genome; MEDLINE; Human genome; Medicine; Biology; Political science; Genetics; Gene; Law","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02124668,0.0005862315,0.001065937,0.00118669,0.02704247,0.01217238,0.003687928,0.0169699,0.004885146],"category_scores_gemma":[0.03721783,0.0004395468,0.00112258,0.001624348,0.01757281,0.004251639,0.005413143,0.02347157,0.0004048155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.08465937,"about_ca_system_score_gemma":0.4396915,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9651471,"about_ca_topic_score_gemma":0.9796675,"domain_scores_codex":[0.9766892,0.00503493,0.0009447974,0.0014732,0.0107201,0.005137683],"domain_scores_gemma":[0.9466434,0.01929446,0.002021387,0.001073382,0.01744844,0.013519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001377351,0.0001646672,0.008278644,0.0005913345,0.00008809812,0.003472019,0.01702574,0.001002786,0.002198406,0.3862954,0.4798239,0.1009213],"study_design_scores_gemma":[0.0001093784,0.00009239653,0.008359703,0.002078135,0.0001200316,0.002200564,0.02669353,0.001460742,0.001255646,0.1069233,0.850186,0.0005206391],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.004964258,0.009592326,0.001055754,0.9707482,0.00161255,0.00003746213,0.00008536759,0.00002606561,0.01187805],"genre_scores_gemma":[0.2122127,0.02964004,0.01045877,0.7219328,0.001795358,0.0001035881,0.0002124504,0.0001102447,0.02353408],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.08465937,"threshold_uncertainty_score":0.6142496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525060593346302,"score_gpt":0.2917916374935215,"score_spread":0.2765410315600585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}