{"id":"W4410202499","doi":"10.7202/1117873ar","title":"Human Genome Editing and Sickle Cell Disease in Canada: Urgent and Unresolved Ethical Considerations","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Bioethics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University","funders":"Social Sciences and Humanities Research Council of Canada","keywords":"Disease; Genome; MEDLINE; Human genome; Medicine; Biology; Political science; Genetics; Gene; Law","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002168683,0.00006992809,0.00009513148,0.00008411108,0.0001010443,0.00002678965,0.00004479842,0.0001097148,0.000009715086],"category_scores_gemma":[0.0002631297,0.00007499203,0.00001870014,0.00004321084,0.0001125298,0.000001673701,0.00001799081,0.000358749,4.414571e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006430524,"about_ca_system_score_gemma":0.004557133,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.318675,"about_ca_topic_score_gemma":0.9743291,"domain_scores_codex":[0.9994671,0.00003281553,0.0001961637,0.00009768186,0.00005552677,0.0001506493],"domain_scores_gemma":[0.9993251,0.00002690656,0.00003899493,0.00007503179,0.0000774277,0.0004565661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007031188,0.00005070673,0.3863812,0.0009072162,0.0003117425,0.001795614,0.00247814,0.01901858,0.5484665,0.01958536,0.01938505,0.001549561],"study_design_scores_gemma":[0.004404972,0.0004675862,0.800875,0.000655267,0.0003115386,0.0002135744,0.005396571,0.001836924,0.09089013,0.00609793,0.08742746,0.001423014],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855568,0.00655808,0.0004888394,0.006906395,0.000198046,0.00006331749,0.00003231304,7.71537e-7,0.0001953894],"genre_scores_gemma":[0.9983324,0.0001069995,0.000198401,0.001223564,0.00008759589,8.310424e-7,0.000005619493,0.000005313493,0.00003930604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6556541,"threshold_uncertainty_score":0.8084158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525060593346302,"score_gpt":0.2917916374935215,"score_spread":0.2765410315600585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}