{"id":"W4410203609","doi":"10.1101/2025.05.02.651925","title":"High-Throughput Evaluation of Cryoprotective Agents for Mixture Effects That Reduce Toxicity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institutes of Health","keywords":"Toxicity; Dimethyl sulfoxide; Diethylene glycol; Glycerol; Vitrification; Chemistry; Cryopreservation; Propanediol; Toxicology; Ethylene glycol; Biology; Organic chemistry; Medicine; Embryo; Andrology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009946025,0.0006683991,0.0009289453,0.000660745,0.0003795209,0.0007755791,0.0005370613,0.0005405243,0.0008935635],"category_scores_gemma":[0.0008093906,0.0002622793,0.0007324049,0.0005925493,0.0002431494,0.0005593675,0.000421639,0.0008249815,0.0003596345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00064922,"about_ca_system_score_gemma":0.0004219981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143074,"about_ca_topic_score_gemma":0.001791548,"domain_scores_codex":[0.999396,0.0001125126,0.00005152142,0.0001106866,0.0002874566,0.00004186338],"domain_scores_gemma":[0.9996247,0.000123866,0.00006721179,0.00003552418,0.0001140141,0.00003462262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303611,0.0001357342,0.0008671036,0.000194199,0.00006840582,0.00003361663,0.00001959646,0.003058322,0.9890408,0.00007405368,0.0002673437,0.006110458],"study_design_scores_gemma":[0.00001124648,0.0006381267,0.003621891,0.00001256283,0.00009813102,0.00007115455,0.00002064339,0.007736271,0.9857028,0.00007294461,0.001998964,0.00001516282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519171,0.007332262,0.0324927,0.0003495163,0.00007890155,0.0004204683,0.004545048,0.0006495283,0.002214467],"genre_scores_gemma":[0.9437467,0.006650046,0.03961738,0.0002371359,0.00003694013,0.0005009531,0.005773429,0.0001653683,0.003272097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143074,"threshold_uncertainty_score":0.00526005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0397766779540398,"score_gpt":0.3038322817983181,"score_spread":0.2640556038442783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}