{"id":"W4410211481","doi":"10.3390/antiox14050560","title":"Hydrogen Sulfide (H2S) Metabolism, Iron Overload, and Apoptosis–Autophagy Equilibrium in Vascular Smooth Muscle Cells","year":2025,"lang":"en","type":"article","venue":"Antioxidants","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Autophagy; Vascular smooth muscle; Cell biology; Downregulation and upregulation; Oxidative stress; Ferritin; Chemistry; Apoptosis; Unfolded protein response; Reactive oxygen species; Signal transduction; Biology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308277,0.0001563212,0.0001762193,0.0001869395,0.0001685433,0.0002211843,0.00009767497,0.0002325236,0.0003451571],"category_scores_gemma":[0.00005391743,0.00007854372,0.0001365838,0.00009943223,0.0002762027,0.0001588624,0.0001549437,0.0002392421,0.00006178744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002941674,"about_ca_system_score_gemma":0.0002068814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000617891,"about_ca_topic_score_gemma":0.00116108,"domain_scores_codex":[0.9999275,0.00001623151,0.000004888218,0.00001449387,0.00001818426,0.00001867853],"domain_scores_gemma":[0.9999563,0.00000379091,0.00001505082,0.000003797749,0.000006356225,0.00001486992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004062445,0.00003464551,0.001828154,0.0000337432,0.000009972653,0.0001149166,0.00003511657,0.00007395857,0.9948723,0.0002174474,0.00005191189,0.002321615],"study_design_scores_gemma":[0.00003714239,0.0006825525,0.05315756,0.00001425139,0.00002873552,0.0004305322,0.0002402494,0.001787503,0.9406474,0.0005329206,0.002431537,0.0000096775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957923,0.002091462,0.001247425,0.000143341,0.0000164935,0.000006961763,0.00005367983,0.0000222929,0.0006259466],"genre_scores_gemma":[0.9981522,0.0006429967,0.0004538517,0.00003222441,0.000008124501,0.00000556844,0.00004107568,0.000001818107,0.0006622272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000617891,"threshold_uncertainty_score":0.002134323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006827383040314033,"score_gpt":0.2393698372738255,"score_spread":0.2325424542335115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}