{"id":"W4410211602","doi":"10.3390/microorganisms13051091","title":"Reducing Functional Domain of Histatin 5 Improves Antifungal Activity and Prevents Proteolytic Degradation","year":2025,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canada Foundation for Innovation","keywords":"Candida albicans; Peptide; Saliva; Corpus albicans; Biochemistry; Chemistry; Fluconazole; Proteolytic enzymes; Microbiology; Mechanism of action; Antifungal; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466716,0.0001381791,0.000222692,0.00009757906,0.0001826137,0.0000174238,0.00007591426,0.0001310954,0.0001255626],"category_scores_gemma":[0.00002938239,0.0001308754,0.00004816947,0.0001069459,0.0002393906,0.0001294781,0.00008990649,0.0001627503,0.0000133069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004124246,"about_ca_system_score_gemma":0.00009452501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002199218,"about_ca_topic_score_gemma":0.00001193042,"domain_scores_codex":[0.9992539,0.00008330122,0.0002025833,0.0002512412,0.00002219829,0.0001867253],"domain_scores_gemma":[0.9996195,0.00006132923,0.0001336227,0.0001363455,0.00003953312,0.000009656746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241559,0.0001037082,0.0005030452,0.00008740359,0.00008946186,5.043176e-7,0.0001672248,8.483178e-7,0.9882888,0.0007566949,0.001453688,0.008424519],"study_design_scores_gemma":[0.0006757815,0.00007261396,0.02640143,0.0000843616,0.00003546303,0.00001730529,0.0001969216,0.000001808083,0.9711015,0.0006087195,0.0006918528,0.0001122139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939147,0.0003931827,0.004352579,0.0001910643,0.0003297743,0.0002817591,0.00003553341,0.00003315523,0.0004682205],"genre_scores_gemma":[0.9885374,0.00001621872,0.001250269,0.00005403396,0.00001242993,0.000008070505,0.00004215466,0.00001059471,0.01006886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02589838,"threshold_uncertainty_score":0.5336943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007450474474373704,"score_gpt":0.2138889282246532,"score_spread":0.2064384537502795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}