{"id":"W4410211602","doi":"10.3390/microorganisms13051091","title":"Reducing Functional Domain of Histatin 5 Improves Antifungal Activity and Prevents Proteolytic Degradation","year":2025,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canada Foundation for Innovation","keywords":"Candida albicans; Peptide; Saliva; Corpus albicans; Biochemistry; Chemistry; Fluconazole; Proteolytic enzymes; Microbiology; Mechanism of action; Antifungal; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310879,0.0003010615,0.0001581139,0.0001061585,0.00006485359,0.0001689243,0.000165242,0.0002604679,0.000809376],"category_scores_gemma":[0.0001669289,0.00009316494,0.0002185544,0.00009505483,0.0001604165,0.0001974772,0.0001535457,0.0003914277,0.0001743532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001313856,"about_ca_system_score_gemma":0.0001278975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003043895,"about_ca_topic_score_gemma":0.0003226394,"domain_scores_codex":[0.9998903,0.00001894178,0.00001432268,0.0000226778,0.00002934823,0.00002440604],"domain_scores_gemma":[0.9999225,0.0000152689,0.00002782526,0.000005991106,0.00001389404,0.00001444057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004103791,0.00001141975,0.00006557077,0.00002295201,0.00000233404,0.00001849785,0.000005340531,0.00003365227,0.9989887,0.00001521219,0.000008834975,0.0007863631],"study_design_scores_gemma":[0.000006373823,0.0001903565,0.001110071,0.000002867657,0.00001198619,0.00008924372,0.000009869843,0.0002744683,0.9975703,0.000008563668,0.0007233083,0.000002426116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969408,0.0006527838,0.001823159,0.00003061838,0.00001180259,0.0000163606,0.00006203294,0.0000182602,0.0004440985],"genre_scores_gemma":[0.9946033,0.0004484575,0.003647741,0.00006626749,0.000004379552,0.00001435151,0.0002376373,0.00001338959,0.000964424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000809376,"threshold_uncertainty_score":0.002707601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007450474474373704,"score_gpt":0.2138889282246532,"score_spread":0.2064384537502795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}