{"id":"W4410213138","doi":"10.1136/bmjmed-2024-001132","title":"Statins for primary prevention of cardiovascular events in people with HIV: target trial and modelling study","year":2025,"lang":"en","type":"article","venue":"BMJ Medicine","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Maple Leaf Medical Clinic; University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institute of Nursing Research; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Eye Institute; National Institute on Aging; Gilead Sciences; National Cancer Institute; National Science Foundation; Canadian Institutes of Health Research; National Human Genome Research Institute; Health Resources and Services Administration; Centers for Disease Control and Prevention; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; ViiV Healthcare; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; Eli Lilly and Company; Government of Alberta; Agency for Healthcare Research and Quality","keywords":"Medicine; Hazard ratio; Myocardial infarction; Stroke (engine); Internal medicine; Unstable angina; Type 2 diabetes; Angina; Cohort; Diabetes mellitus; Coronary artery disease; Confidence interval; Statin; Cohort study; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006038876,0.00009981955,0.0005555329,0.0001983864,0.00004727341,8.107684e-7,0.00003256571,0.00004183799,0.000006308277],"category_scores_gemma":[0.00005725043,0.00007060742,0.00004876622,0.0002907254,0.00002455685,0.0000288027,0.00001371101,0.00008488075,5.24405e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007449571,"about_ca_system_score_gemma":0.0002241852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002981206,"about_ca_topic_score_gemma":0.00003936704,"domain_scores_codex":[0.9989079,0.00006522828,0.0004413837,0.0002234835,0.0002306566,0.0001313352],"domain_scores_gemma":[0.999363,0.0001014397,0.00009439151,0.0002747516,0.0001102646,0.00005615284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07129882,0.009357478,0.8594779,0.004515129,0.005162925,0.00004280158,0.008533621,0.01115998,0.00004463345,0.0006303184,0.001154902,0.02862155],"study_design_scores_gemma":[0.4687698,0.0148316,0.4808637,0.004568952,0.003610884,0.00002096404,0.002901832,0.02024993,0.00002256149,0.001315892,0.00261018,0.0002336735],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9201126,0.001755866,0.06903118,0.0009925532,0.00006255822,0.007412184,0.000007646247,0.00001485228,0.0006106239],"genre_scores_gemma":[0.9932413,0.0001625457,0.004893829,0.00004946769,0.00005148259,0.0007713489,0.0001144153,0.00001177103,0.000703831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.397471,"threshold_uncertainty_score":0.2879287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03239978800230166,"score_gpt":0.3596771444048795,"score_spread":0.3272773564025778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}