{"id":"W4410213138","doi":"10.1136/bmjmed-2024-001132","title":"Statins for primary prevention of cardiovascular events in people with HIV: target trial and modelling study","year":2025,"lang":"en","type":"article","venue":"BMJ Medicine","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Maple Leaf Medical Clinic; University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institute of Nursing Research; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Eye Institute; National Institute on Aging; Gilead Sciences; National Cancer Institute; National Science Foundation; Canadian Institutes of Health Research; National Human Genome Research Institute; Health Resources and Services Administration; Centers for Disease Control and Prevention; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; ViiV Healthcare; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; Eli Lilly and Company; Government of Alberta; Agency for Healthcare Research and Quality","keywords":"Medicine; Hazard ratio; Myocardial infarction; Stroke (engine); Internal medicine; Unstable angina; Type 2 diabetes; Angina; Cohort; Diabetes mellitus; Coronary artery disease; Confidence interval; Statin; Cohort study; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006125625,0.001548592,0.00349662,0.0004126512,0.0002619028,0.0009682808,0.001480627,0.001092119,0.003551547],"category_scores_gemma":[0.009232982,0.0006188111,0.003312796,0.0007945926,0.0002509062,0.0006988898,0.0008508766,0.001272137,0.000479934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007304863,"about_ca_system_score_gemma":0.00184459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007618448,"about_ca_topic_score_gemma":0.004667076,"domain_scores_codex":[0.9974564,0.002042972,0.00007889482,0.0001703327,0.000111437,0.0001399138],"domain_scores_gemma":[0.9974372,0.001662882,0.0003817719,0.0001929311,0.0001606759,0.00016448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.4417448,0.0100343,0.0899983,0.008164725,0.05816473,0.001008057,0.0006087673,0.2778951,0.002937921,0.008251096,0.02883364,0.0723586],"study_design_scores_gemma":[0.2691477,0.03031011,0.04132985,0.001059026,0.04858818,0.0006380115,0.0002662602,0.5872996,0.001145352,0.01217155,0.007710238,0.0003342279],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9424402,0.01322982,0.02036044,0.0052316,0.0004787634,0.002290895,0.01065984,0.0004092851,0.00489927],"genre_scores_gemma":[0.9777548,0.003621412,0.008568208,0.0006485361,0.0002967511,0.003023837,0.003652259,0.00005351607,0.002380716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007618448,"threshold_uncertainty_score":0.03239578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03239978800230166,"score_gpt":0.3596771444048795,"score_spread":0.3272773564025778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}