{"id":"W4410217287","doi":"10.20944/preprints202505.0407.v1","title":"From Bone Health to Gut Shield: A Reanalysis & Meta‑Analysis of Long‑Term Oral Bisphosphonates in Colorectal Cancer Prevention","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero della Salute","keywords":"Medicine; Colorectal cancer; Meta-analysis; Term (time); Bone health; Internal medicine; Oncology; Cancer; Osteoporosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02860206,0.004104626,0.01787736,0.008025345,0.000779982,0.00426526,0.002822084,0.002551845,0.005304098],"category_scores_gemma":[0.04520485,0.002032184,0.09366464,0.008558638,0.0008519114,0.002015263,0.002599799,0.002871123,0.000777539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001980311,"about_ca_system_score_gemma":0.004086315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009823689,"about_ca_topic_score_gemma":0.01514989,"domain_scores_codex":[0.9761707,0.01398786,0.004260515,0.002441528,0.002262122,0.00087729],"domain_scores_gemma":[0.9778751,0.01526566,0.002748054,0.001997085,0.001776564,0.0003376112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002165291,0.00001066956,0.005105008,0.06007794,0.9250931,0.00009414747,0.00004822332,0.0005778907,0.0001866983,0.0001427366,0.0008810902,0.005617285],"study_design_scores_gemma":[0.0004578903,0.0001201783,0.002981841,0.003591343,0.990665,0.00005288712,0.0000262475,0.0003027334,0.0000798529,0.0002288803,0.001472166,0.00002111354],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01149234,0.978318,0.004597193,0.000741252,0.0008537431,0.0004862144,0.002671398,0.0002011258,0.0006388675],"genre_scores_gemma":[0.5916256,0.3821037,0.01385786,0.00223992,0.001045491,0.003248689,0.003363309,0.0003345776,0.002180792],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02860206,"threshold_uncertainty_score":0.1512639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1650247183084396,"score_gpt":0.4514106485502125,"score_spread":0.2863859302417728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}