{"id":"W4410217362","doi":"10.1016/s2468-1253(25)00017-2","title":"Long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis: an interim analysis of the phase 3 U-ACTIVATE long-term extension study","year":2025,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"AbbVie; National Institutes of Health; Pfizer; Eli Lilly and Company","keywords":"Ulcerative colitis; Interim; Term (time); Interim analysis; Medicine; Internal medicine; Clinical trial; Physics; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0108445,0.001016192,0.002182491,0.0003662963,0.0006959251,0.001479772,0.0006590808,0.0009406728,0.002203515],"category_scores_gemma":[0.004661101,0.0004141925,0.003406814,0.0004651601,0.0005916739,0.001035188,0.0006908215,0.002654458,0.0006247123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005446868,"about_ca_system_score_gemma":0.001430783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003142701,"about_ca_topic_score_gemma":0.000686316,"domain_scores_codex":[0.9975757,0.001419089,0.0001589306,0.0001796129,0.0002425666,0.000424134],"domain_scores_gemma":[0.9951704,0.001146587,0.001503486,0.0007954987,0.0004968843,0.0008871776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8592864,0.01004794,0.05128624,0.0008012648,0.004502073,0.000354075,0.0002708991,0.002193542,0.00903349,0.0002798387,0.005026111,0.05691814],"study_design_scores_gemma":[0.2458916,0.5409105,0.1805993,0.0002785297,0.009270922,0.001139603,0.0002656487,0.003400462,0.007580292,0.0007247067,0.009782609,0.0001558628],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987672,0.00330151,0.001307701,0.0003993976,0.0001207068,0.001876349,0.002779344,0.000106244,0.002436764],"genre_scores_gemma":[0.9900804,0.0005802655,0.00162089,0.0006067372,0.0001280745,0.001680197,0.004408943,0.00002181424,0.0008726289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0108445,"threshold_uncertainty_score":0.05735189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134999474407167,"score_gpt":0.2936457272283411,"score_spread":0.2801457797876244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}