{"id":"W4410221878","doi":"10.1016/j.xphs.2025.103823","title":"Relationships between surface tensiometry properties and fluorescence intensity of dark and light exposed monoclonal antibody Nivolumab/Opdivo® by using the contact angle method: A pilot study","year":2025,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Horizon 2020 Framework Programme; Innovative Medicines Initiative; Istituto Oncologico Veneto; European Commission; Innovative Health Initiative; European Federation of Pharmaceutical Industries and Associations","keywords":"Nivolumab; Contact angle; Fluorescence; Monoclonal antibody; Intensity (physics); Materials science; Analytical Chemistry (journal); Optics; Chemistry; Chromatography; Antibody; Composite material; Physics; Medicine; Immunology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002867812,0.00008747214,0.0001980413,0.00005108495,0.0003017173,0.0000495032,0.0002124909,0.00003854712,0.000002212636],"category_scores_gemma":[0.0005458843,0.00005191867,0.00003037474,0.0002856548,0.0004530913,0.00002267614,0.0001260007,0.0002143923,5.385119e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001246135,"about_ca_system_score_gemma":0.0001195678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003164378,"about_ca_topic_score_gemma":0.000003074059,"domain_scores_codex":[0.9987039,0.0003944784,0.0003478934,0.0001961909,0.0002305979,0.000126963],"domain_scores_gemma":[0.9992812,0.0001119348,0.0001745435,0.0001048881,0.000240234,0.00008723135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411969,0.0001201013,0.291387,0.00001254842,0.00003454404,4.842741e-7,0.00008781346,0.000004965109,0.7074065,0.00001581467,0.00003407977,0.000755002],"study_design_scores_gemma":[0.0009213398,0.001652914,0.2488422,0.00006414125,0.0001336275,0.00002792147,0.002142044,0.002102429,0.7431733,0.0001940035,0.000607579,0.000138539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917797,0.004303853,0.00257573,0.001016088,0.00005541245,0.0002269243,0.000005698912,0.000002020817,0.000034566],"genre_scores_gemma":[0.9973584,0.0001107946,0.002434918,0.00005806219,0.00002148953,6.325069e-7,5.341759e-7,0.000002161712,0.00001303851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04254484,"threshold_uncertainty_score":0.2320596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1580352510777771,"score_gpt":0.4001090245727583,"score_spread":0.2420737734949813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}