{"id":"W4410223395","doi":"10.2196/62951","title":"Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Baclofen; Spasticity; Placebo; Botulinum toxin; Medicine; Randomized controlled trial; Stroke (engine); Adverse effect; Modified Ashworth scale; Anesthesia; Physical therapy; Physical medicine and rehabilitation; Surgery; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02729649,0.008220435,0.01273124,0.002338145,0.003614134,0.003532857,0.003202919,0.008355143,0.0540792],"category_scores_gemma":[0.02602951,0.002687369,0.006501962,0.003297891,0.003936974,0.003158827,0.001924773,0.007241685,0.01057883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00442669,"about_ca_system_score_gemma":0.0131004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00187697,"about_ca_topic_score_gemma":0.003765557,"domain_scores_codex":[0.9753117,0.01436495,0.002973825,0.00233836,0.00239762,0.002613493],"domain_scores_gemma":[0.9856398,0.003118621,0.003471065,0.001770878,0.003865084,0.002134446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9556319,0.009275719,0.0004749399,0.009048537,0.001668123,0.0001171669,0.0001795787,0.001184718,0.001699456,0.001770747,0.006278989,0.01267012],"study_design_scores_gemma":[0.965564,0.01884259,0.0009567446,0.000842669,0.0007014789,0.00002994574,0.00003797772,0.001085112,0.0004878247,0.0008428546,0.01054702,0.00006189422],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.003550261,0.0003168247,0.001460165,0.0001727078,0.0004466997,0.9919772,0.0008895298,0.0001169762,0.001069702],"genre_scores_gemma":[0.004682646,0.0001833711,0.001898587,0.0001885771,0.00008583136,0.9923047,0.0002051776,0.000009340824,0.0004417135],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0540792,"threshold_uncertainty_score":0.180913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1381413399563337,"score_gpt":0.5180461611478586,"score_spread":0.3799048211915249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}