{"id":"W4410233027","doi":"10.1101/2025.05.08.652952","title":"Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Hippo signaling pathway; Cell biology; Biology; Cadherin; Regulator; Nuclear localization sequence; Chromatin immunoprecipitation; Chromatin; Gene; Cell nucleus; Regulation of gene expression; Nucleus; Signal transduction; Gene expression; Genetics; Cell; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009413718,0.0002369737,0.0001578683,0.000170583,0.0001193683,0.0002192887,0.0001540475,0.0002203383,0.002350067],"category_scores_gemma":[0.0001039559,0.0001180506,0.0002497502,0.0001309406,0.0002010041,0.0001495084,0.0001962816,0.0005566168,0.0006563544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003516687,"about_ca_system_score_gemma":0.0002182562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009458308,"about_ca_topic_score_gemma":0.002567247,"domain_scores_codex":[0.9999231,0.000004600417,0.000003583277,0.00002245547,0.00002358411,0.00002263085],"domain_scores_gemma":[0.9999328,0.00001917698,0.00001062248,0.00001240658,0.000007626513,0.00001737937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002782884,0.00000567831,0.0001823333,0.00001756215,0.000002406488,0.00003778721,0.000009361469,0.00001735171,0.9986244,0.0001174924,0.00004333346,0.0009145091],"study_design_scores_gemma":[0.0000101446,0.00005111669,0.009120744,0.000004884471,0.00000509234,0.0001473611,0.00003350742,0.00057455,0.9875401,0.00006321136,0.00244699,0.000002403479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803587,0.001304167,0.01310397,0.0001919914,0.00007060032,0.00003196955,0.001447013,0.0002328852,0.003258711],"genre_scores_gemma":[0.9870251,0.000347332,0.004300929,0.0001159781,0.000008867937,0.00002303841,0.002334837,0.00005528356,0.005788603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002350067,"threshold_uncertainty_score":0.007861733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009432799556584819,"score_gpt":0.2142926466955224,"score_spread":0.2048598471389376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}