{"id":"W4410236307","doi":"10.3390/cancers17101609","title":"Continuing Cyclin-Dependent Kinase 4/6 Inhibitors Beyond Progression in Advanced Breast Cancer: A Meta-Analysis","year":2025,"lang":"en","type":"review","venue":"Cancers","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; St. Michael's Hospital; Lakeridge Health; Queen's University; Lakeshore General Hospital; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; Health Sciences North; University of Toronto","funders":"","keywords":"Palbociclib; Medicine; Oncology; Internal medicine; Breast cancer; Cyclin-dependent kinase; Cyclin-dependent kinase 4; Metastatic breast cancer; Cancer; Cyclin-dependent kinase 2; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01888107,0.002959331,0.01418876,0.004517145,0.0006670449,0.003417786,0.002048449,0.002029308,0.003166199],"category_scores_gemma":[0.02798024,0.001455366,0.05668972,0.00578844,0.000649806,0.001675508,0.001511185,0.002107021,0.0003334965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001980782,"about_ca_system_score_gemma":0.002052471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006383952,"about_ca_topic_score_gemma":0.01169545,"domain_scores_codex":[0.9876794,0.00741752,0.002219232,0.001386484,0.0008511465,0.0004462431],"domain_scores_gemma":[0.9717542,0.02240003,0.003111946,0.001056276,0.001269376,0.0004080904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004754917,0.00002704753,0.008418115,0.06947208,0.9108483,0.0001297003,0.00004210042,0.0009702916,0.0002198736,0.00008533694,0.0003807714,0.004651441],"study_design_scores_gemma":[0.0006115536,0.0001739924,0.003402166,0.00291148,0.99192,0.00005442155,0.00001667511,0.0002691716,0.00006887833,0.0001014771,0.0004582083,0.00001195345],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02690482,0.9694623,0.001309773,0.0003237642,0.000232147,0.0002840478,0.0008586776,0.00005911718,0.0005653051],"genre_scores_gemma":[0.6671687,0.3247389,0.003287455,0.001142339,0.0004318672,0.00108506,0.001443408,0.00006806712,0.000634158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01888107,"threshold_uncertainty_score":0.09985381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03523666760996913,"score_gpt":0.3882565185404877,"score_spread":0.3530198509305186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}