{"id":"W4410241330","doi":"10.1002/psp4.70033","title":"Virtual Clinical Trial Reveals Significant Clinical Potential of Targeting Tumor‐Associated Macrophages and Microglia to Treat Glioblastoma","year":2025,"lang":"en","type":"article","venue":"CPT Pharmacometrics & Systems Pharmacology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Université de Montréal; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Microglia; Nivolumab; CD8; Medicine; Glioblastoma; CD47; Clinical trial; Cancer research; Immune system; Tumor microenvironment; Immunotherapy; Oncology; Immunology; Internal medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006219901,0.0004512807,0.0006336729,0.0001602953,0.0001207163,0.000611421,0.0003210289,0.0004435784,0.002966581],"category_scores_gemma":[0.0007849924,0.0001052831,0.000527161,0.0001068513,0.000290904,0.0003819684,0.0002671273,0.0005961893,0.0002360552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004818924,"about_ca_system_score_gemma":0.000970276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008936576,"about_ca_topic_score_gemma":0.001281651,"domain_scores_codex":[0.9998766,0.00006128746,0.000004436321,0.00001913897,0.00001485832,0.0000236782],"domain_scores_gemma":[0.9998159,0.00007528257,0.00003319968,0.00001436609,0.0000134599,0.00004777837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.08354799,0.01087607,0.008654278,0.002429719,0.001254967,0.0007261599,0.0001259509,0.360952,0.08379014,0.02134856,0.02355565,0.4027386],"study_design_scores_gemma":[0.02612793,0.1100707,0.009089959,0.000202818,0.001645724,0.0007115425,0.0001237036,0.7750643,0.03137675,0.02015281,0.02530495,0.0001288195],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622303,0.005981986,0.01698757,0.003477125,0.0005822161,0.0003681244,0.0009592885,0.0005887814,0.008824456],"genre_scores_gemma":[0.9943203,0.0009226616,0.002451696,0.0003868815,0.00004428271,0.0001908213,0.0003354477,0.00001757297,0.001330281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002966581,"threshold_uncertainty_score":0.009924233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932385224291486,"score_gpt":0.3780810019834003,"score_spread":0.3487571497404855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}