{"id":"W4410243556","doi":"10.3390/ijms26104519","title":"Clinical Validation of Plasma Metabolite Markers for Early Lung Cancer Detection","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; St. Boniface Hospital; CancerCare Manitoba; University of Manitoba; The Metabolomics Innovation Centre; Université Laval; University of Alberta","funders":"Fonds de Recherche du Québec - Santé; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval","keywords":"Medicine; Cohort; Receiver operating characteristic; Oncology; Lung cancer; Internal medicine; Stage (stratigraphy); Logistic regression; Metabolomics; Area under the curve; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005828687,0.0006327827,0.0006419013,0.0006008933,0.0002957977,0.0009593479,0.000426167,0.000604463,0.0005280519],"category_scores_gemma":[0.01026717,0.0001973699,0.000380622,0.0005274116,0.0003951907,0.0003458178,0.000509466,0.0005283348,0.0002731781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000262801,"about_ca_system_score_gemma":0.0006413917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000720493,"about_ca_topic_score_gemma":0.0009062911,"domain_scores_codex":[0.9972576,0.001500597,0.0001804657,0.0004871372,0.0004862579,0.00008795111],"domain_scores_gemma":[0.9968957,0.001538462,0.0006174513,0.0003438848,0.0004877108,0.0001167712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003300284,0.0004355789,0.862506,0.000271853,0.0008073055,0.000383981,0.0002284686,0.005293846,0.06405511,0.0003442586,0.0009273332,0.06144595],"study_design_scores_gemma":[0.0002503734,0.003473032,0.89062,0.0001259033,0.0007753296,0.002101308,0.0002535662,0.04011951,0.05539731,0.001266868,0.005552825,0.00006408742],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726567,0.004160445,0.0200801,0.0003583205,0.00005483055,0.0001981937,0.001409632,0.0001325332,0.000949169],"genre_scores_gemma":[0.9930518,0.0004608213,0.005198933,0.0001614971,0.00003086804,0.00006038311,0.0008544388,0.00001126525,0.0001699858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005828687,"threshold_uncertainty_score":0.03082544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874438746320644,"score_gpt":0.4306853983898046,"score_spread":0.4119410109265981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}