{"id":"W4410249012","doi":"10.1101/2025.05.03.652000","title":"MAIT cell responses to intracellular and extracellular pathogens are mediated by distinct antigen presenting cells","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Science Foundation","keywords":"Francisella tularensis; Biology; Extracellular; Antigen presentation; Intracellular; Cell biology; Cell type; Microbiology; T cell; Antigen-presenting cell; Cell; Immune system; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068873,0.0003856573,0.0001887948,0.0001671561,0.0001551776,0.0004141085,0.0001147469,0.000225855,0.003086049],"category_scores_gemma":[0.0001307715,0.0000816294,0.0002232633,0.00006126193,0.0002545857,0.0001994577,0.0002835763,0.0005051553,0.0009822985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613283,"about_ca_system_score_gemma":0.0001130048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001201744,"about_ca_topic_score_gemma":0.00008534578,"domain_scores_codex":[0.9998645,0.00002495164,0.000009059657,0.00003157225,0.00002662596,0.00004336828],"domain_scores_gemma":[0.9999076,0.00001442285,0.00001889757,0.00001220525,0.00001303552,0.00003384416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001979066,0.00001824731,0.001374932,0.00004749373,0.00000468287,0.0001463567,0.00004100666,0.00004145338,0.9944369,0.0004815025,0.0001118659,0.003097716],"study_design_scores_gemma":[0.00006652196,0.0006315564,0.02426449,0.00003370773,0.00003568918,0.002227319,0.0002360712,0.002139762,0.95909,0.0006307498,0.01063368,0.00001038758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878541,0.002019906,0.00448978,0.0001791839,0.00007716515,0.00002344336,0.0001936534,0.00009904602,0.005063714],"genre_scores_gemma":[0.9943124,0.0005150537,0.001669766,0.00006824865,0.00005177492,0.00002281792,0.0002471662,0.00001507632,0.003097701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003086049,"threshold_uncertainty_score":0.01032388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0092506036811668,"score_gpt":0.2053474885716484,"score_spread":0.1960968848904816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}