{"id":"W4410252080","doi":"10.3390/ph18050700","title":"Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders","year":2025,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Repurposing; Sigma-1 receptor; Medicine; Neuroprotection; Drug repositioning; Drug development; Pharmacology; Context (archaeology); Drug; Fluvoxamine; Receptor; Biology; Fluoxetine; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003500508,0.0009232782,0.0008980565,0.002000696,0.0002699508,0.0007247529,0.0006584938,0.0007665809,0.004658523],"category_scores_gemma":[0.0003654074,0.0002580679,0.0004190413,0.002110982,0.000337018,0.001026981,0.0005714338,0.001633459,0.002980527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004736649,"about_ca_system_score_gemma":0.0006844205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005925196,"about_ca_topic_score_gemma":0.001418349,"domain_scores_codex":[0.9998716,0.00001820634,0.00001449476,0.00002573786,0.00005305438,0.00001688262],"domain_scores_gemma":[0.9998553,0.0000590085,0.00002419183,0.000006275826,0.00004080303,0.000014426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006394002,0.0000887121,0.000102731,0.0167952,0.00007382543,0.0002201386,0.00008626047,0.0005618574,0.006585915,0.005898703,0.02842649,0.9410962],"study_design_scores_gemma":[0.00001488019,0.00008751799,0.0003738565,0.001466231,0.00006335948,0.0006357304,0.00003995346,0.0001056543,0.001091168,0.001802086,0.9943066,0.00001295977],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003200863,0.9964433,0.0003901006,0.0002044721,0.0002289044,0.0000121074,0.00004320423,0.00002433543,0.002333487],"genre_scores_gemma":[0.001109935,0.9968289,0.0004183119,0.0001781536,0.0001088769,0.00001294304,0.00004928588,0.000003395916,0.001290192],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004658523,"threshold_uncertainty_score":0.01558429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0333971623598202,"score_gpt":0.4167466836523264,"score_spread":0.3833495212925062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}