{"id":"W4410255805","doi":"10.1016/j.lungcan.2025.108579","title":"Intracranial and systemic progression on amivantamab in platinum-treated epidermal growth factor receptor exon 20 insertion-mutated advanced non-small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Epidermal growth factor receptor; Exon; Lung cancer; Cancer research; Oncology; Epidermal growth factor; Receptor; Mutation; Internal medicine; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000662616,0.0003837575,0.0005623733,0.0003049288,0.0001587443,0.00003998899,0.0000928151,0.0002089896,0.0001898016],"category_scores_gemma":[0.00003385107,0.0003107389,0.00007758379,0.0005682771,0.00005164682,0.0001737905,0.00004150543,0.0003477458,0.000005359302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00154102,"about_ca_system_score_gemma":0.0006142019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002446338,"about_ca_topic_score_gemma":0.001326365,"domain_scores_codex":[0.9980571,0.00007387275,0.0005160503,0.0006393761,0.0002440576,0.0004695134],"domain_scores_gemma":[0.9990871,0.0001117347,0.0002030371,0.0002456042,0.0001853852,0.0001671595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001880495,0.0003880319,0.9155286,0.001902998,0.0003999713,0.00008911682,0.001659573,0.0004323125,0.05532122,0.00002806353,0.001428734,0.02094088],"study_design_scores_gemma":[0.0308048,0.0007568088,0.8564128,0.02005023,0.00168488,0.00002953485,0.0006150527,0.01974231,0.06805807,0.00002336712,0.0007909039,0.001031208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874089,0.00648165,0.0001026724,0.001006943,0.0008112155,0.002532308,0.0002185799,0.0001301324,0.001307615],"genre_scores_gemma":[0.9941313,0.001511878,0.0003231056,0.0003755477,0.0001617747,0.001237987,0.0001680835,0.0000545266,0.002035824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05911578,"threshold_uncertainty_score":0.9999345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006628700707250518,"score_gpt":0.3154210073877967,"score_spread":0.3087923066805461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}