{"id":"W4410264327","doi":"10.1016/j.exphem.2025.104801","title":"NAMPT-mediated deacetylation of HCLS1 protein promotes clonogenic growth of pediatric CML cells","year":2025,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Wilhelm Sander-Stiftung","keywords":"Clonogenic assay; Acetylation; Cancer research; Chemistry; Cell biology; Biology; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079468,0.0001555191,0.0002731936,0.0001042155,0.00003747991,0.000003355672,0.0001795045,0.0002204771,0.00006355892],"category_scores_gemma":[0.00005704118,0.0001557233,0.0001042136,0.0001798942,0.0001114539,0.000004091523,0.0001345344,0.00006866688,0.00001042166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001283756,"about_ca_system_score_gemma":0.0001030024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001977603,"about_ca_topic_score_gemma":0.0000028308,"domain_scores_codex":[0.9989378,0.00009688584,0.0003842383,0.0002847441,0.00009326102,0.0002030546],"domain_scores_gemma":[0.9994231,0.00002101096,0.0001946723,0.000235848,0.00008274754,0.00004257858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001298136,0.0002574748,0.003454924,0.0001729772,0.00004453756,0.000001449154,0.0001003121,5.277004e-7,0.989998,0.0054494,0.0003593697,0.0000312142],"study_design_scores_gemma":[0.0007029527,0.0004030818,0.0001766005,0.00002038658,0.00001370692,0.000006652637,0.00008757877,0.00001861245,0.9981151,0.0001733721,0.00015995,0.000121962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900511,0.007576435,0.0002630431,0.0000429681,0.0001480677,0.0005941531,0.00002713131,0.0000154345,0.001281694],"genre_scores_gemma":[0.998219,0.00003456403,0.001242967,0.00003978044,0.0000594115,0.0001087248,0.00009729502,0.00001479601,0.0001835223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008167866,"threshold_uncertainty_score":0.6350214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008711175651863598,"score_gpt":0.256742809468166,"score_spread":0.2480316338163024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}