{"id":"W4410265736","doi":"10.1002/alz.70209","title":"Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Montreal Neurological Institute and Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; HORIZON EUROPE Framework Programme; Olav Thon Stiftelsen; Instituto Serrapilheira; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Vetenskapsrådet; EU Joint Programme – Neurodegenerative Disease Research; National Institute on Aging; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute; Parkinsonfonden; Hjärnfonden; International Society for Neurochemistry; BrightFocus Foundation; Gun och Bertil Stohnes Stiftelse; European Commission; Fondation Brain Canada; Stiftelsen för Gamla Tjänarinnor","keywords":"Glial fibrillary acidic protein; Positron emission tomography; Clinical trial; Alzheimer's disease; Amyloid beta; Population; Nuclear medicine; Pathology; Psychology; Medicine; Oncology; Internal medicine; Disease; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06974491,0.001031404,0.001423426,0.001089547,0.0003654827,0.001475544,0.0008830745,0.001305678,0.004088938],"category_scores_gemma":[0.1198245,0.0004822132,0.002492303,0.0008471705,0.0009474209,0.00103257,0.001293936,0.00100449,0.0005432811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001274107,"about_ca_system_score_gemma":0.002938658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005536732,"about_ca_topic_score_gemma":0.0006166018,"domain_scores_codex":[0.9154679,0.07621292,0.002232017,0.001947685,0.00354972,0.0005897981],"domain_scores_gemma":[0.9140369,0.06392302,0.01298348,0.00371073,0.004064366,0.00128146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1111635,0.002189114,0.09940684,0.01468973,0.02088998,0.0008656076,0.0007967168,0.1093304,0.01828261,0.03036354,0.009261832,0.5827602],"study_design_scores_gemma":[0.03985044,0.1185786,0.2641591,0.009110192,0.03813852,0.002438196,0.0006464496,0.2264295,0.03714985,0.1203794,0.1424931,0.0006266089],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4339981,0.03356261,0.4266226,0.007534282,0.001608191,0.06240434,0.004021869,0.001136609,0.02911139],"genre_scores_gemma":[0.8499997,0.002031743,0.1238583,0.001241895,0.0001910762,0.02087491,0.0005148044,0.00005203063,0.001235533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06974491,"threshold_uncertainty_score":0.3688508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2135465084716378,"score_gpt":0.510083963388944,"score_spread":0.2965374549173062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}