{"id":"W4410266122","doi":"10.1016/j.drup.2025.101251","title":"MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Princess Margaret Cancer Centre; University Health Network","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"PTEN; Downregulation and upregulation; Head and neck squamous-cell carcinoma; Cancer research; microRNA; PI3K/AKT/mTOR pathway; Head and neck; Mechanism (biology); Medicine; Head and neck cancer; Basal cell; Oncology; Internal medicine; Biology; Cancer; Signal transduction; Gene; Genetics; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002310387,0.000355313,0.0004648522,0.000211127,0.00009431734,0.00002554914,0.0005469698,0.0002466265,0.00002804871],"category_scores_gemma":[0.0002009534,0.0003843919,0.0001741198,0.0005982344,0.0001606042,0.00001095344,0.0001844316,0.00007620296,0.00001464372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000960211,"about_ca_system_score_gemma":0.0003310826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001544221,"about_ca_topic_score_gemma":0.001604924,"domain_scores_codex":[0.9976202,0.00007027297,0.0007732556,0.000742341,0.0003427417,0.0004511955],"domain_scores_gemma":[0.9980111,0.00007128835,0.0004184041,0.0009302453,0.0004401149,0.0001288299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008600213,0.0001522664,0.001538652,0.0003780093,0.00003899723,0.000002360144,0.0002311968,0.0001757053,0.9839229,0.0001838392,0.01246415,0.0000519035],"study_design_scores_gemma":[0.00139481,0.00007705975,0.005246752,0.0002266876,0.00005758933,8.153025e-7,0.0001112942,0.0000254595,0.9733973,0.0003875994,0.01872211,0.0003525486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898766,0.003560619,0.003512513,0.000429539,0.0003063316,0.0005732315,0.0002668011,0.00002502695,0.00144939],"genre_scores_gemma":[0.9846965,0.00004912595,0.007970169,0.0002908298,0.0001034462,0.00007162536,0.000290001,0.00005193554,0.006476334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052563,"threshold_uncertainty_score":0.9998608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005825822523603009,"score_gpt":0.2379051853537052,"score_spread":0.2320793628301022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}