{"id":"W4410271217","doi":"10.1164/ajrccm.2025.211.abstracts.a3396","title":"Akt1 is Essential for Follicular Helper T Cell Development","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Follicular phase; AKT1; Immunology; Cell biology; Internal medicine; Signal transduction; PI3K/AKT/mTOR pathway; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397361,0.0004301495,0.0001842822,0.000280821,0.0003230186,0.0004365233,0.0002875178,0.0003546506,0.002950291],"category_scores_gemma":[0.0001284947,0.0002322902,0.0002494351,0.0001339143,0.0002201544,0.0001914914,0.0002722008,0.0005693633,0.001200199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088429,"about_ca_system_score_gemma":0.0003500701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444287,"about_ca_topic_score_gemma":0.000581564,"domain_scores_codex":[0.9998153,0.00002061036,0.00001781536,0.00004736531,0.00004011593,0.00005887051],"domain_scores_gemma":[0.9997266,0.00001963665,0.0001040759,0.00002269522,0.00002731432,0.0000997359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002453181,0.00003265709,0.001345058,0.00009443463,0.000009909947,0.0001462222,0.00001376393,0.0001081708,0.9950345,0.0002958489,0.0002904359,0.002383701],"study_design_scores_gemma":[0.0001131642,0.0004085721,0.05313068,0.00004776707,0.00006150288,0.001515747,0.0001000306,0.003339458,0.9204202,0.000666904,0.02017072,0.00002527645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864521,0.004096831,0.003257762,0.0003125046,0.0001598333,0.00003049425,0.002056309,0.0003780188,0.003256189],"genre_scores_gemma":[0.9940402,0.0008750602,0.001067581,0.00006021365,0.00002355434,0.00002088658,0.001074558,0.00003911591,0.002798868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002950291,"threshold_uncertainty_score":0.009869695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023341031474076,"score_gpt":0.2869739953646649,"score_spread":0.2767405850499242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}