{"id":"W4410271448","doi":"10.1164/ajrccm.2025.211.abstracts.a3114","title":"Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Sepsis-associated Acute Respiratory Failure: A Phase 3 Randomized Placebo-controlled Trial","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Ganciclovir; Placebo; Cytomegalovirus; Randomized controlled trial; Acute respiratory failure; Sepsis; Internal medicine; Respiratory failure; Intensive care medicine; Immunology; Mechanical ventilation; Herpesviridae; Viral disease; Human cytomegalovirus; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002401465,0.001448302,0.003761522,0.0004360743,0.0004843962,0.001413294,0.0009254083,0.002089723,0.005925224],"category_scores_gemma":[0.002569692,0.0005478708,0.002875754,0.0005144037,0.0009142437,0.0009402597,0.00035391,0.002207375,0.0006366598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006989054,"about_ca_system_score_gemma":0.001361553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009687601,"about_ca_topic_score_gemma":0.002032706,"domain_scores_codex":[0.9990973,0.0005164072,0.00008028001,0.0001426961,0.00005892543,0.0001043693],"domain_scores_gemma":[0.9989225,0.0003811452,0.0002805803,0.00008376626,0.0001069449,0.0002249934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9810116,0.003342478,0.0003996787,0.001631301,0.00141001,0.00003060972,0.00003133627,0.0001752463,0.001258548,0.00007386182,0.0005477203,0.01008761],"study_design_scores_gemma":[0.9845065,0.01402108,0.0005478394,0.00006828242,0.0003750814,0.00001100114,0.000008714173,0.0001157191,0.00009360707,0.00005330082,0.0001930221,0.000005777266],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508061,0.02945732,0.001190902,0.001729753,0.00148821,0.01071472,0.001829922,0.0002167849,0.002566126],"genre_scores_gemma":[0.970747,0.009363676,0.002042503,0.001955436,0.0007870664,0.01219549,0.0009313487,0.00002258129,0.001954993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005925224,"threshold_uncertainty_score":0.01982188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380234393663782,"score_gpt":0.3467857148543849,"score_spread":0.332983370917747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}