{"id":"W4410272123","doi":"10.1164/ajrccm.2025.211.abstracts.a3446","title":"ZW1528, A Bispecific Antibody Targeting IL-4Rα and IL-33, Potently Inhibits Key Mediators of Airway Inflammation","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Medicine; Inflammation; Immunology; Antibody; Bispecific antibody; Airway; Interleukin 6; Interleukin 23; Interleukin 17; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002740332,0.0007647087,0.00027176,0.0003499782,0.00009893106,0.0002126768,0.000449087,0.000496718,0.002313557],"category_scores_gemma":[0.0001171783,0.0002000772,0.0002946536,0.0001444881,0.0003157495,0.0001872994,0.0002547974,0.0007407661,0.001095424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711554,"about_ca_system_score_gemma":0.0002655998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002692891,"about_ca_topic_score_gemma":0.0003548676,"domain_scores_codex":[0.9997631,0.00003992575,0.00001980719,0.00005216126,0.00008271088,0.00004238817],"domain_scores_gemma":[0.9999106,0.00001133487,0.00003206738,0.000006480466,0.00001093436,0.0000285525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009290129,0.00003942943,0.00007607081,0.00007595974,0.000006755616,0.00002524858,0.000005370239,0.0001330742,0.9974967,0.0001497931,0.00008305022,0.001815676],"study_design_scores_gemma":[0.0001207917,0.001242658,0.001154597,0.00001741922,0.00002846332,0.0005125569,0.000009177646,0.0008935894,0.9904992,0.00005574858,0.005459358,0.000006460941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537218,0.007242442,0.029178,0.0005071623,0.0001389461,0.0005791411,0.0007298538,0.0003696334,0.007533085],"genre_scores_gemma":[0.9698565,0.003164806,0.01891367,0.0002119984,0.0000395441,0.0003257455,0.001109542,0.00003383041,0.006344392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002313557,"threshold_uncertainty_score":0.007739604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008363902913403283,"score_gpt":0.2746814259101339,"score_spread":0.2663175229967307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}