{"id":"W4410272725","doi":"10.1164/ajrccm.2025.211.abstracts.a4036","title":"Systemic Exposure of Budesonide/Glycopyrrolate/Formoterol Fumarate With Hydrofluoroolefin-1234ze Versus Hydrofluoroalkane-134a Propellants Administered Via Metered-Dose Inhaler With a Spacer in Healthy Adults","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Glycopyrrolate; Metered-dose inhaler; Formoterol Fumarate; Budesonide; Inhaler; Anesthesia; Propellant; Asthma; Pharmacology; Inhalation; Internal medicine; Formoterol; Organic chemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001389123,0.0009003785,0.001386779,0.0002063196,0.0003686527,0.0005947591,0.0005102521,0.001201686,0.002881421],"category_scores_gemma":[0.001293632,0.0005535677,0.001159429,0.000235423,0.0006255684,0.0006996655,0.0003144838,0.001284914,0.0004350927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005179509,"about_ca_system_score_gemma":0.000821488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009076608,"about_ca_topic_score_gemma":0.001614835,"domain_scores_codex":[0.9991114,0.0003837816,0.00006701692,0.0002179019,0.00009759519,0.0001223049],"domain_scores_gemma":[0.9992126,0.0001794681,0.0002201682,0.00005075278,0.0000671575,0.0002698583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.9457142,0.02126008,0.006655592,0.0004718885,0.0008446266,0.00004024505,0.00007237769,0.000233608,0.01331939,0.00003531123,0.0003121376,0.0110405],"study_design_scores_gemma":[0.2136881,0.7507395,0.03039867,0.00003101736,0.001175308,0.00005291267,0.0000497353,0.0003761062,0.002877632,0.00006988477,0.0005211706,0.00002002929],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997808,0.0007248266,0.0001472829,0.00005542589,0.00006207133,0.0006476864,0.0002557189,0.00001208379,0.0002869372],"genre_scores_gemma":[0.9973046,0.0003258097,0.000388036,0.0001576951,0.0001001248,0.0009060465,0.0002067156,0.000003787743,0.0006071876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881421,"threshold_uncertainty_score":0.009639263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150709938168218,"score_gpt":0.2992226609753809,"score_spread":0.2841516671585591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}