{"id":"W4410274704","doi":"10.1164/ajrccm.2025.211.abstracts.a5547","title":"Efficacy of Tezepelumab on Upper and Lower Airway Outcomes in Adults With Severe, Uncontrolled Chronic Rhinosinusitis With Nasal Polyps in Patients With and Without Comorbid Asthma: Results from the Phase 3 Waypoint Study","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Nasal polyps; Chronic rhinosinusitis; Asthma; Airway; Sinusitis; Internal medicine; Respiratory tract; Waypoint; Chronic sinusitis; Gastroenterology; Immunology; Respiratory system; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002217477,0.001137495,0.002065618,0.0002708812,0.000362783,0.001073772,0.0007333097,0.001062732,0.003181832],"category_scores_gemma":[0.001704761,0.0003657234,0.003507899,0.0003229349,0.0006775767,0.0009937698,0.0004463617,0.002035463,0.0003920494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006133883,"about_ca_system_score_gemma":0.0008351671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007161553,"about_ca_topic_score_gemma":0.002247901,"domain_scores_codex":[0.9992229,0.0003828805,0.00006201972,0.0001353934,0.00008211516,0.0001146678],"domain_scores_gemma":[0.9987863,0.0003154433,0.0003828381,0.0001121118,0.0001196036,0.0002836877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9070363,0.01091403,0.01413401,0.001634642,0.005645209,0.0001122508,0.0001925333,0.0007363526,0.01126062,0.0001174777,0.001789187,0.04642751],"study_design_scores_gemma":[0.7138201,0.2126919,0.06554971,0.0001113928,0.003490834,0.0002031757,0.0001021412,0.0006276011,0.001420902,0.0001677,0.00175756,0.00005710379],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992772,0.004839526,0.0001451213,0.0001822153,0.00006327417,0.0005561221,0.0007935429,0.00003255165,0.0006156573],"genre_scores_gemma":[0.9951764,0.001594402,0.0004527672,0.000353532,0.0001084312,0.0007720405,0.001003103,0.000009769432,0.0005294571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003181832,"threshold_uncertainty_score":0.01172727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006710284429456198,"score_gpt":0.289659688114869,"score_spread":0.2829494036854128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}