{"id":"W4410276658","doi":"10.1164/ajrccm.2025.211.abstracts.a7746","title":"ING-006, A Novel Oral GPR40/GPR84 Fatty Acid Receptor Modulator: A Comparative Study With Nintedanib and Nerandomilast (BI-1015550) in Bleomycin-induced Lung Fibrosis and CAM-IPF Xenograft Models","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Bausch Health (Canada)","funders":"","keywords":"Nintedanib; Medicine; Free fatty acid receptor 1; Idiopathic pulmonary fibrosis; Bleomycin; Receptor; Cancer research; Lung; Internal medicine; Agonist; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921033,0.0004104393,0.0007153466,0.0003519902,0.0001244816,0.0001769225,0.0003073783,0.0003151652,0.001062067],"category_scores_gemma":[0.0001067891,0.0001437581,0.0004051508,0.0002176693,0.0002287534,0.0003238515,0.0001204236,0.0006591508,0.0002490575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747687,"about_ca_system_score_gemma":0.0001980252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005232046,"about_ca_topic_score_gemma":0.001259229,"domain_scores_codex":[0.9999186,0.0000172883,0.000007783686,0.00001600562,0.00001408445,0.00002631073],"domain_scores_gemma":[0.9999387,0.000008078585,0.00001398915,0.000005806889,0.000005725003,0.00002770011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01597445,0.004102917,0.0006715661,0.0004953988,0.0001133307,0.0001803908,0.00005743781,0.0003727972,0.9547592,0.0001133782,0.000350579,0.02280859],"study_design_scores_gemma":[0.005559701,0.1584429,0.02438174,0.00004804096,0.0007657434,0.001265591,0.0002396136,0.002368898,0.7971009,0.0001232315,0.009640828,0.00006268603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949905,0.002784939,0.000503944,0.0001007301,0.00004189375,0.00008816731,0.0003323223,0.0000620589,0.001095543],"genre_scores_gemma":[0.992869,0.003115949,0.001130366,0.0001074086,0.00002500242,0.0001120138,0.0008066021,0.00001118212,0.001822514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062067,"threshold_uncertainty_score":0.003552973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810877872120137,"score_gpt":0.36412144691432,"score_spread":0.3360126681931186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}