{"id":"W4410279612","doi":"10.20944/preprints202505.0572.v1","title":"Sesamin Suppresses Aging-Associated Impairment of Protein Homeostasis in Adult <em>Drosophila </em>Muscles by Stimulating Autophagy","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Sesame and Sesamin Research","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Autophagy; Homeostasis; Drosophila (subgenus); Cell biology; Biology; Endocrinology; Internal medicine; Medicine; Genetics; Apoptosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001687441,0.0007811015,0.001257326,0.0001944411,0.0002722399,0.0001431137,0.001808865,0.0008640654,0.001462639],"category_scores_gemma":[0.002063066,0.0004440455,0.0004928316,0.001063651,0.0002026739,0.000191379,0.003561654,0.001286456,0.00009833135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003843099,"about_ca_system_score_gemma":0.0001878751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002878923,"about_ca_topic_score_gemma":0.002354412,"domain_scores_codex":[0.9932941,0.0008650805,0.001450686,0.001861004,0.001359056,0.001170128],"domain_scores_gemma":[0.9967819,0.0008661218,0.0007323972,0.0006432639,0.0006974663,0.0002788804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002313707,0.002225311,0.2438847,0.0009082353,0.0003666781,0.00006197187,0.001906378,0.0009500111,0.7215502,0.0001371791,0.0005473802,0.02723057],"study_design_scores_gemma":[0.0009424464,0.0002807894,0.8019873,0.001913812,0.00007225112,0.000002282113,0.0008521033,0.001091525,0.1894414,0.001223868,0.00121294,0.0009792306],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930009,0.0009009083,0.000002178354,0.001092119,0.0002293783,0.002395865,0.001161604,0.0002450865,0.0009719174],"genre_scores_gemma":[0.9955924,0.0005809905,0.00009501146,0.0001294258,0.0001497629,0.0005893885,0.0008366656,0.00001098226,0.002015442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5581027,"threshold_uncertainty_score":0.9998012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06430470260340465,"score_gpt":0.3175710781049727,"score_spread":0.2532663755015681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}