{"id":"W4410283464","doi":"10.1016/j.bioactmat.2025.04.034","title":"Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism","year":2025,"lang":"en","type":"article","venue":"Bioactive Materials","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Dental follicle; Reprogramming; Extracellular vesicles; Cell biology; Chemistry; Extracellular; Vesicle; Pulpitis; Metabolism; Stem cell; Cell; Medicine; Biology; Biochemistry; Dentistry; Membrane; Pulp (tooth)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691335,0.000347549,0.0003759502,0.0003140425,0.0001332073,0.0003182595,0.000164736,0.0003811749,0.0008465637],"category_scores_gemma":[0.00008727259,0.0001028423,0.0004444853,0.0001045473,0.0002385215,0.0003399225,0.0003275684,0.0006194533,0.0001538259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001566095,"about_ca_system_score_gemma":0.0003171996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002651587,"about_ca_topic_score_gemma":0.0004929993,"domain_scores_codex":[0.9998783,0.00001795922,0.00001289149,0.00001895978,0.00003220093,0.00003977923],"domain_scores_gemma":[0.999964,0.00000414579,0.00001271678,0.000004021044,0.000005887289,0.00000925872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005667242,0.0001901017,0.0003175353,0.0003234988,0.00002097481,0.0001181794,0.00004921323,0.0001145183,0.9848681,0.000264415,0.0001630268,0.01300379],"study_design_scores_gemma":[0.0001718558,0.002526795,0.005330341,0.00005167031,0.000149997,0.0004889992,0.0001677087,0.0011131,0.9790614,0.0003841322,0.01053685,0.000017243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829456,0.009927009,0.004653947,0.0002231726,0.0001305118,0.00009843825,0.0002296679,0.0001418284,0.001649752],"genre_scores_gemma":[0.9911792,0.004806482,0.002078187,0.0001337685,0.00003284905,0.00008213104,0.0002269935,0.00001950973,0.001440935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008465637,"threshold_uncertainty_score":0.002832055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008041887213132945,"score_gpt":0.2332302890232259,"score_spread":0.2251884018100929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}