{"id":"W4410283643","doi":"10.1038/s44320-025-00106-4","title":"Metabolic mapping of the human solute carrier superfamily","year":2025,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"European Commission","keywords":"Biology; Metabolomics; Solute carrier family; Transcriptome; Computational biology; Metabolic pathway; SUPERFAMILY; Function (biology); Biochemistry; Transporter; Cell biology; Gene; Gene expression; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931697,0.0001040008,0.0002228085,0.00002697012,0.00009579493,0.000007914631,0.0003462285,0.00007105601,0.00003134156],"category_scores_gemma":[0.00005748841,0.00006431661,0.0001051152,0.0002016794,0.0002154551,0.00001651905,0.0003044888,0.00009316632,0.0000112477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002246277,"about_ca_system_score_gemma":0.000007492984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001976892,"about_ca_topic_score_gemma":0.0000134063,"domain_scores_codex":[0.9990835,0.0001709995,0.0002304943,0.0002206728,0.00007663461,0.0002177608],"domain_scores_gemma":[0.99949,0.00003097746,0.00007400435,0.0003699498,0.000009092831,0.00002597867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[6.762912e-7,0.00001200004,0.06695326,0.00002165745,0.00003131851,0.000001708662,0.0000344185,0.0001212123,0.9276474,0.004459427,0.0004340286,0.000282904],"study_design_scores_gemma":[0.0006974427,0.00004989144,0.1438213,0.0001666599,0.00009197868,0.00001580862,0.0001683826,0.0004965888,0.7417052,0.001169673,0.1112631,0.0003539174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842891,0.001272612,0.0004963023,0.0001322667,0.0003452878,0.0002212179,0.000007821633,0.00001717812,0.01321825],"genre_scores_gemma":[0.9990587,0.000007963295,0.0000461817,0.0001637966,0.00001582006,0.00001996652,0.000003291494,0.000006506043,0.000677785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1859421,"threshold_uncertainty_score":0.2988482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00840021648958096,"score_gpt":0.3025911222246605,"score_spread":0.2941909057350796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}