{"id":"W4410286350","doi":"10.1021/acs.jmedchem.5c00302","title":"Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite <i>Plasmodium falciparum</i>","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"University of Capetown; Medical Research Council; South African Medical Research Council; University of Cape Town; National Research Foundation; Medicines for Malaria Venture; University of Sussex","keywords":"Plasmodium falciparum; Malaria; Parasite hosting; Chemistry; Identification (biology); Apicomplexa; Phenotype; Plasmodium (life cycle); Malarial parasites; Computational biology; Immunology; Biology; Biochemistry; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076856,0.0003450006,0.000397056,0.0003364732,0.0001599731,0.0003508478,0.0002808135,0.0002246546,0.00254815],"category_scores_gemma":[0.0001987362,0.0001708244,0.0002354551,0.0003984077,0.0001887854,0.0002002881,0.0002791691,0.0004724408,0.0006897374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347254,"about_ca_system_score_gemma":0.0002473689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006325274,"about_ca_topic_score_gemma":0.002046463,"domain_scores_codex":[0.9998848,0.00002104408,0.00001299747,0.00002209203,0.00002823205,0.00003080459],"domain_scores_gemma":[0.9999216,0.00002312891,0.00001274762,0.00001412622,0.00001514174,0.0000132816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004698778,0.0001962614,0.000773633,0.00007980049,0.00001101866,0.0001668367,0.00005535389,0.0008274117,0.9858983,0.0003043686,0.000423741,0.01079335],"study_design_scores_gemma":[0.0001212538,0.004100608,0.006561244,0.00001450825,0.000038544,0.0005025271,0.00008086836,0.003171408,0.9797961,0.0001733702,0.005417277,0.00002229982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850357,0.001430486,0.004863183,0.0001827492,0.00002831059,0.0002394357,0.001235421,0.0002735213,0.006711246],"genre_scores_gemma":[0.9829017,0.001794386,0.007745638,0.0001104979,0.00001106255,0.0001514574,0.002146888,0.00003350526,0.00510486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254815,"threshold_uncertainty_score":0.008524418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330414820772058,"score_gpt":0.3130373991963342,"score_spread":0.2997332509886136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}