{"id":"W4410286827","doi":"10.1093/cvr/cvaf077","title":"Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics","year":2025,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cerebrovascular and Carotid Artery Diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"Horizon 2020 Framework Programme; Health~Holland; European Commission; Fondation Leducq; St. Antonius Ziekenhuis; Chan Zuckerberg Initiative","keywords":"Proteomics; Transcriptome; Biomarker; Carotid endarterectomy; Glycolysis; Pathology; Biomarker discovery; Medicine; Vulnerable plaque; Pathological; Biology; Bioinformatics; Internal medicine; Gene expression; Biochemistry; Metabolism; Carotid arteries; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005653789,0.0004213481,0.0004872052,0.00123187,0.0003391488,0.0007274085,0.0001441925,0.0004350037,0.001001527],"category_scores_gemma":[0.0009359082,0.0001899102,0.0003443732,0.0009695889,0.0002285513,0.0002357313,0.0005145261,0.0003272681,0.0003999162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412231,"about_ca_system_score_gemma":0.0001646863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000651696,"about_ca_topic_score_gemma":0.0007041747,"domain_scores_codex":[0.999667,0.00003647836,0.00004440879,0.0001375253,0.00006705394,0.00004742165],"domain_scores_gemma":[0.9995103,0.00009688147,0.0002075033,0.00005832554,0.00006815767,0.0000587789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002173033,0.00006541098,0.8597048,0.0002037071,0.0003147824,0.0006822114,0.0002370635,0.0002578326,0.1228233,0.0001130265,0.0005526842,0.01287219],"study_design_scores_gemma":[0.0000122387,0.0001116745,0.9910172,0.00001375434,0.0001124393,0.001240309,0.0001302791,0.000585491,0.005950521,0.0001820416,0.0006352525,0.000008806334],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969982,0.0009506261,0.0005768842,0.00004172627,0.000006193888,0.000005512711,0.001117963,0.00002120825,0.0002818398],"genre_scores_gemma":[0.996708,0.0004381265,0.0007804995,0.00004446192,0.00001524413,0.000009783842,0.001751386,0.000007610536,0.0002448755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123187,"threshold_uncertainty_score":0.003350496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05653503591019866,"score_gpt":0.337972514786612,"score_spread":0.2814374788764133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}