{"id":"W4410299054","doi":"10.1210/endocr/bqaf090","title":"Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion From Human Islets","year":2025,"lang":"en","type":"article","venue":"Endocrinology","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Erasmus+; National Institutes of Health; University of Alberta; Canterbury Medical Research Foundation; Roy J. Carver Charitable Trust; U.S. Department of Veterans Affairs","keywords":"Adipose triglyceride lipase; Internal medicine; Endocrinology; Lipolysis; Secretion; Insulin; Downregulation and upregulation; Glucagon; Adipose tissue; Hormone-sensitive lipase; Triglyceride; Lipid droplet; Islet; Alpha cell; Biology; Beta cell; Chemistry; Medicine; Cholesterol; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312067,0.0002724464,0.0003452103,0.0001448099,0.00009160207,0.0003180441,0.0001306801,0.0002428172,0.001287607],"category_scores_gemma":[0.0001262827,0.0001138174,0.0003226659,0.0001309432,0.0001671227,0.0001636643,0.0002211246,0.0006261634,0.0003610926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001365868,"about_ca_system_score_gemma":0.0001563445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002817172,"about_ca_topic_score_gemma":0.0003862939,"domain_scores_codex":[0.9998589,0.00002282538,0.00002180882,0.00003065042,0.00003401724,0.00003190095],"domain_scores_gemma":[0.9999427,0.00001511599,0.00001165877,0.000009673634,0.000005065507,0.00001589737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008072596,0.0001371035,0.0004439617,0.00009223587,0.00001332656,0.0001165915,0.00002225241,0.00006809782,0.9947336,0.00003356759,0.0001516909,0.003380334],"study_design_scores_gemma":[0.0001091549,0.001747385,0.01020175,0.00001725936,0.00005447791,0.0003182629,0.00006608199,0.0007576008,0.9829049,0.00004639969,0.00376665,0.00001008796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993744,0.003112264,0.001045682,0.0001297698,0.0001209534,0.00003503411,0.0003340174,0.00008545881,0.001392912],"genre_scores_gemma":[0.9944063,0.002012237,0.001174829,0.000198445,0.00003201725,0.00008197239,0.0006918885,0.00002289401,0.001379468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287607,"threshold_uncertainty_score":0.004307508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004704066492575328,"score_gpt":0.2355055789106356,"score_spread":0.2308015124180603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}