{"id":"W4410299634","doi":"10.3390/vaccines13050506","title":"Shigella Mutant with Truncated O-Antigen as an Enteric Multi-Pathogen Vaccine Platform","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Wellcome Trust","keywords":"Shigella; Shigellosis; Shigella flexneri; Microbiology; Biology; Immunogenicity; Campylobacter; Antigen; Adjuvant; Virology; Salmonella; Immunology; Bacteria; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633918,0.0002579445,0.0002484695,0.0001070205,0.00016927,0.00004828289,0.0003455947,0.0001160353,0.00005598613],"category_scores_gemma":[0.0001297797,0.0001897887,0.00006399144,0.0003646853,0.00002436896,0.00001017032,0.0002546013,0.0001107921,0.00001837885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001986536,"about_ca_system_score_gemma":0.0001369862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001166855,"about_ca_topic_score_gemma":0.0006019343,"domain_scores_codex":[0.9986814,0.00004810852,0.0002218655,0.0005065997,0.0001417946,0.0004002678],"domain_scores_gemma":[0.9991684,0.0000153422,0.00006387406,0.0004378105,0.0002068159,0.0001077443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008834641,0.0002221258,0.05997957,0.00004725708,0.0002983641,0.00002141854,0.00009053703,0.00002028647,0.934944,0.00006323025,0.0008287212,0.002601],"study_design_scores_gemma":[0.006370231,0.002371066,0.2921741,0.0001101554,0.0001131177,0.00006259155,0.0008844475,0.00119194,0.597046,0.0001441608,0.09866871,0.0008635513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958905,0.00131542,0.000483416,0.0002702504,0.00008682196,0.0003908768,0.00001931893,0.00005177272,0.001491633],"genre_scores_gemma":[0.9940751,0.0008494583,0.001228107,0.0003417037,0.0001282045,0.00007739128,0.0001167407,0.00003202097,0.003151321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3378981,"threshold_uncertainty_score":0.7739359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373914450508525,"score_gpt":0.2982031282968537,"score_spread":0.2844639837917685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}