{"id":"W4410299634","doi":"10.3390/vaccines13050506","title":"Shigella Mutant with Truncated O-Antigen as an Enteric Multi-Pathogen Vaccine Platform","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Wellcome Trust","keywords":"Shigella; Shigellosis; Shigella flexneri; Microbiology; Biology; Immunogenicity; Campylobacter; Antigen; Adjuvant; Virology; Salmonella; Immunology; Bacteria; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194514,0.0003504792,0.0001884038,0.0001367253,0.00006693102,0.0001895147,0.0002430993,0.0001963599,0.0006477158],"category_scores_gemma":[0.00009351599,0.00007314469,0.000268636,0.0001628524,0.00008737527,0.0002066622,0.0002139879,0.0004253591,0.0002003769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038973,"about_ca_system_score_gemma":0.0002019726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003525176,"about_ca_topic_score_gemma":0.0005005522,"domain_scores_codex":[0.9999192,0.000009372685,0.000008652286,0.00001432648,0.00002802266,0.00002038149],"domain_scores_gemma":[0.9999474,0.000003231735,0.00001900108,0.000007355474,0.00001113864,0.00001193146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003897792,0.00002068543,0.0001088027,0.00002150657,0.000002385418,0.00002085158,0.000003438115,0.00008735809,0.9991634,0.00003245671,0.00001599111,0.0004841406],"study_design_scores_gemma":[0.00000914075,0.0004816166,0.001174483,0.000005838007,0.0000157823,0.0001144379,0.00001687511,0.0009975892,0.9957954,0.00002948695,0.001355745,0.00000366931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949877,0.0003727293,0.003821831,0.00008438691,0.0000216844,0.0000369856,0.0002616717,0.00005218005,0.0003608075],"genre_scores_gemma":[0.9871544,0.0004960356,0.00957239,0.00004846542,0.000006191132,0.00004844274,0.001124175,0.0000282743,0.00152153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006477158,"threshold_uncertainty_score":0.002166867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373914450508525,"score_gpt":0.2982031282968537,"score_spread":0.2844639837917685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}